COMPArative Study of the Consequence on innaTe Immune Response du to Bacterial or Viral Infection in Patients Admitted to Intensive Care Unit

Launched by UNIVERSITY HOSPITAL, LIMOGES · Jan 2, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how the immune system responds to bacterial and viral infections in patients who are admitted to the Intensive Care Unit (ICU). Researchers want to understand the role of immature granulocytes, which are a type of white blood cell that can indicate problems with the immune response. By examining these cells in patients with acute infections, they hope to learn more about how infections can affect the body and how to improve treatment.

To participate in this study, you need to be an adult patient who has been in the ICU for less than 24 hours due to either a documented bacterial infection (like sepsis) or a confirmed viral infection. For bacterial infections, you should be receiving support for your blood pressure and have certain health indicators that suggest a serious condition. For viral infections, you may need to be on high-flow oxygen or require help with breathing. This study is currently recruiting participants, and if you choose to take part, you will undergo tests to analyze your immune response. It's important to note that certain conditions, like recent antibiotic use or a weakened immune system, may prevent you from being eligible for the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Bacterial infection:
• • Adult patient hospitalized for less than 24 hours in ICU for community documented sepsis
• • Vasopressor support
• • SOFA score \> 4
• * Viral infection:
• • Adult patient hospitalized for less than 24 hours in ICU for confirmed viral acute infection.
• • High flow oxygen, non-invasive or invasive ventilation since less than 24 hours
• • Moderate to severe ARDS with PaO2/FiO2 \< 200mmHg and a FiO2 ≥ 0.6.
• Exclusion Criteria:
• * Bacterial infection:
• • Antibiotics or hospitalized in ICU in the previous 3 months
• • Immunocompromized patient
• • Ongoing acute or chronic viral infection
• * Viral infection:
• • Antibiotics or hospitalized in ICU in the previous 3 months
• • Immunocompromized patient
• • Current antibiotics
• • Ongoing chronic viral infection.