Sonographic Diaphragm Function in AECOPD

Launched by ISALA · Dec 20, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how well ultrasound can measure diaphragm function in patients with a severe flare-up of Chronic Obstructive Pulmonary Disease (COPD) who are hospitalized. The main goal is to see if changes in diaphragm activity can help understand how much trouble a patient is having with breathing, as measured by a simple scale called the Borg score, during their hospital stay.

To join the study, participants need to be hospitalized due to a serious COPD exacerbation and meet specific criteria, including having certain lung function test results. The trial is open to adults aged 65 to 74, regardless of gender. Participants will have their diaphragm assessed using ultrasound, which is a painless imaging technique, and will provide information that might help doctors better manage breathing difficulties in the future. It’s important to note that patients with certain conditions, like severe respiratory problems or those who are pregnant, cannot participate. If you meet the criteria and are interested, you can discuss this opportunity with your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Hospitalisation primarily because of severe acute exacerbation of COPD
• • COPD, according to GOLD 2018 definition
• • Post-bronchodilator FEV1/FVC \< 0,70 and FEV1% \< 80%pred. within last 5 years
• Exclusion Criteria:
• • Respiratory acidosis (pH \< 7.35 ánd PaCO2 \> 6 kPA)
• • Need for (non-)invasive ventilation based on other criteria (e.g. severe hypoxia) upon presentation.
• • Established diagnosis of diaphragm diaphragm paralysis.
• • Inability for diaphragm imaging (e.g. mechanical ventilation, or unable to follow vocal instructions).
• • Those not able or unwilling to give written informed consent.
• • Pregnant women