PRP for Glenohumeral Osteoarthritis

Launched by HOSPITAL FOR SPECIAL SURGERY, NEW YORK · Dec 28, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called platelet-rich plasma (PRP) for people with shoulder osteoarthritis. This condition can cause pain and stiffness in the shoulder joint, making daily activities difficult. The trial will compare the effects of two different doses of PRP injections—low-dose and high-dose—against a placebo (saline solution) to see which one works best for relieving pain and improving function in the shoulder.

To be eligible for this study, participants must be between 18 and 100 years old and have experienced shoulder pain rated at least 5 out of 10 for three months or longer, despite trying other treatments like physical therapy. They should also have had some temporary relief from pain after receiving a diagnostic injection into the joint. Participants can expect to receive one injection and will be monitored for their pain levels and any changes in their shoulder function over time. It’s important to note that certain medical conditions and previous treatments may exclude individuals from participating in the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-100 years old
• • Average NRS pain greater than or equal to 5/10 as a direct result of glenohumeral osteoarthritis (any severity: mild, moderate, or severe) and/or chondral lesion or loss
• • At least 3 months of pain after onset of symptoms that has failed conservative treatments, including physical therapy
• • MRI of the affected joint
• • Transient relief of symptoms after a diagnostic intra-articular injection into the joint
• • Email address or network access
• Exclusion Criteria:
• • Inability to hold non-steroidal anti-inflammatory drugs for 2 weeks prior and 1 month after the injection
• • Prior platelet-rich plasma injection
• • Steroid injection within 3 months of the initial injection
• • Hyaluronic acid within 6 months of the initial injection
• • Involved in workers' compensation or active litigation involving the affected joint
• • History of Plavix use
• • Known uncontrolled systemic illness (uncontrolled diabetes, HIV, vasculitis, autoimmune/autoinflammatory disease)
• • Presence of acute fractures or gross mechanical deformities
• • Concurrent "uncontrolled" cervical disorders