The Impact of Preoperative Olanzapine on Quality of Recovery After Discharge from Ambulatory Surgery

Launched by YALE UNIVERSITY · Jan 6, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at whether taking a medication called olanzapine before surgery can help improve recovery for patients after they go home. Specifically, the study focuses on women aged 18 to 50 who are scheduled for outpatient surgery that requires general anesthesia. Researchers want to see if taking olanzapine helps reduce nausea and improves overall recovery quality, as measured by a survey on the first and second days after surgery.

To participate in this trial, women must be able to give informed consent, be comfortable using a smartphone or computer, and have no significant health issues that might complicate their surgery or recovery. Participants will be randomly assigned to either receive olanzapine or a placebo (a "dummy" pill with no active medication) before their surgery. Throughout the study, they will be asked about their recovery experiences, including any nausea they might feel after going home. This trial is important because it could help improve how patients feel and recover after surgery.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Provision of signed and dated informed consent form
• • Stated willingness to comply with all study procedures and availability for the duration of the study
• • Female aged 18-50
• • Scheduled to undergo ambulatory surgery under general anesthesia
• • Access to smartphone device or computer with internet connection and has an email address
• Exclusion Criteria:
• • Non-English speaking
• • Unable to swallow pills
• • Current use of anti-psychotic medications
• • History of allergy to olanzapine
• • Pregnancy/Lactation
• • Current use of antihypertensive medication
• • Diabetes Mellitus
• * Clinically significant cardiovascular disease defined as follows:
• • 1. Myocardial infarction or unstable angina within 6 months prior to the day of planned surgery.
• • 2. History of serious ventricular arrhythmia (i.e.: ventricular tachycardia or ventricular fibrillation) or cardiac arrhythmias requiring anti-arrhythmic medications, except for atrial fibrillation that is well controlled on anti-arrhythmic medication.
• • 3. New York Heart Association Class II or higher congestive heart failure.
• • 4. Postural hypotension or vasovagal syncope within 6 months of planned surgery.
• • Hypotension on day of surgery, defined as a systolic blood pressure \< 90mmHg
• • Seizure disorder
• • Clinically active prolactinoma
• • Hepatic disease
• • Narrow angle glaucoma
• • Parkinson's disease
• • Lewy body dementia