Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease

Launched by CHINESE PLA GENERAL HOSPITAL · Dec 28, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the relationship between two types of brain diseases: intracranial atherosclerosis (narrowing of the arteries in the brain) and cerebral small vessel disease (problems with the small blood vessels in the brain). The goal is to understand how these conditions affect each other and how they influence disease progression and outcomes. Researchers will use advanced imaging techniques to identify early signs that could help prevent or treat these conditions more effectively.

To participate in this study, you need to be at least 18 years old and have a significant narrowing (50% or more) in at least one of your brain's arteries. Additionally, you should have a good level of mental function. However, if you have serious narrowing in arteries outside the brain, are pregnant, or have certain medical devices that prevent MRI scans, you won't be eligible. If you join the study, you can expect to undergo imaging tests and contribute to important research that may help improve treatment for these brain conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • At least one intracranial artery ≥ 50% atherosclerotic stenosis
• • Modified Rankin Scale \< 2
• • Mini-mental State Examination \> 24
• Exclusion Criteria:
• • Concurrent ipsilateral extracranial artery ≥ 50% stenosis
• • Pregnant women
• • Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)