Early Neurological Deterioration in Recent Small Subcortical Infarction

Launched by YUAN GAO · Dec 25, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at a condition called recent small subcortical infarction (RSSI), which involves small areas of brain damage caused by a lack of blood flow. While many patients with RSSI generally have a good outlook, some experience early neurological deterioration (END), which means their symptoms may worsen shortly after the initial injury. The study aims to find out more about the risk factors that lead to this deterioration and to develop a tool that can help doctors predict who might be at risk and how to manage their care effectively.

To be eligible for this study, participants need to be at least 18 years old and have experienced symptoms of a stroke within the last 72 hours. They must also have completed specific brain imaging tests to confirm the diagnosis. If you decide to participate, you'll be part of a larger group of patients being monitored to collect important information that could help improve future treatments for this condition. Importantly, the study is still recruiting participants, so there's an opportunity to contribute to valuable research that could benefit many people in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years;
• • 2. Time from the last seen normal to enrollment ≤ 72 h.
• • 3. Completion of brain MRI (T1/T2/Flair/DWI sequences at least). The lesion belonged to the territory of the penetrating artery( lenticulostriate area and pons) on the DWI sequence and at least one of the vascular examinations such as MRA, CTA or DSA was completed.
• Exclusion Criteria:
• • 1. Patients with low imaging quality affecting the evaluation of the data;
• • 2. Vascular malformations, aneurysms, intracranial hemorrhagic diseases, brain abscesses, malignant space occupying lesions or other non-ischemic intracranial lesions;
• • 3. Patients with combined malignancy, hematological disease and other systemic diseases with possible hypercoagulable state;
• • 4. pre-stroke mRS ≥2 ;
• • 5. END occurred before the completion of brain MRI after admission;
• • 6. Acute endovascular treatment had been received or was planed to be done;
• • 7. Pregnant or lactating women;
• • 8. Participating in another ongoing study;
• • 9. Refused to participate in the study.