Bed Rest on the Effect of CSF Leakage Repair After Transsphenoidal Pituitary Surgery

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · Dec 27, 2022

Keywords

ClinConnect Summary

Postoperative CSF leakage is a well-known complication that might occur after transnasal transsphenoidal adenomectomy at an incidence of 0.5-15% according to different literature reports. Persistent CSF leakage may lead to intracranial hypotension or meningitis, therefore aggressive management is mandatory. The reason that a postoperative CSF leakage would occur mostly is due to the rupture of arachnoid membrane caused by intraoperative manipulation, resulting in direct communication between the subarachnoid space and the nasal cavity. Even when in cases without intraoperative CSF leakage d...

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Eligibility criteria

• Inclusion Criteria:
• • Patients with pituitary adenoma requiring surgical resection.
• Exclusion Criteria:
• • Spontaneous CSF leakage occurs prior to transsphenoidal surgery.
• • The growth of adenoma extends to anterior cranial fossa or clival region.
• • The growth of adenoma extends to 3rd ventricle.
• • Prior history of transsphenoidal surgery.
• • Prior history of radiotherapy or radiosurgery to the sella or nearby skull base region.
• • Class 2 obesity or extremely obese: BMI ≧35.
• • Pregnant or lactating women.
• • Patients who could not give informed consent.