Barrett's Esophagus and Esophageal Adenocarcinoma, Searching for Reliable Diagnostic RNA Plasma-based Biomarkers

Launched by UNIVERSITY HOSPITAL, GHENT · Jan 13, 2023

Keywords

ClinConnect Summary

This clinical trial is looking for new ways to diagnose two conditions: Barrett's esophagus, which is a change in the cells lining the esophagus, and esophageal adenocarcinoma, a type of cancer. The researchers want to find specific markers in the blood that could help identify these conditions more accurately. This study is currently recruiting participants who are between the ages of 18 and 74 and have either Barrett's esophagus that is longer than 3 centimeters or have been diagnosed with esophageal adenocarcinoma.

To join the trial, participants should have a clear understanding of the study and be able to give their consent. It's important that they do not have other types of cancer, severe organ problems, or active infections. They should not be pregnant or breastfeeding and must not be part of other clinical trials that might interfere with this one. If eligible, participants can expect to provide blood samples and undergo some evaluations to help researchers learn more about these diseases and improve future diagnosis methods.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Barrett's Esophagus with length \> 3cm OR esophageal adenocarcinoma histologically proven
• • Adequate mental faculty, allowing to understand the proposed treatment protocol and provide informed consent
• • Age over 18 years
• • No other concurrent malignant disease
• • No inclusion in other clinical trials interfering with the study protocol
• • No concurrent chronic systemic immune or hormone therapy, except neoadjuvant chemotherapy
• • Absence of any severe organ insufficiency
• • No pregnancy or breast feeding
• • Written informed consent
• Exclusion Criteria:
• • Pregnancy or breast feeding
• • Active bacterial, viral or fungal infection
• • Parenchymal liver disease (any stage cirrhosis)
• • High risk of bleeding during biopsy (anticoagulants, esophageal varices)
• • Esophageal squamous cell carcinoma
• • Helicobacter pylori positive at the time of biopsy sampling
• • Radiofrequency ablation of the oesophagus
• • Psychiatric pathology capable of affecting comprehension and judgement faculty