A Study of MRG003 in the Treatment of Patients With EGFR-positive Advanced or Metastatic Solid Tumors

Launched by SHANGHAI MIRACOGEN INC. · Jan 15, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called MRG003, which is being tested for its safety and effectiveness in patients with certain types of advanced solid tumors that have a specific marker known as EGFR. This includes cancers like non-small cell lung cancer and head and neck cancers. The trial is currently looking for participants aged 18 to 75 who are willing to follow the study guidelines and have measurable tumors. To be eligible, patients should not have severe heart or liver problems and should be able to live for at least 12 weeks.

Participants in this study will receive MRG003 in combination with another drug called HX008. Throughout the trial, they will be closely monitored to see how well the treatment works and if there are any side effects. It's important for patients to understand that this is an early-stage study, which means it's one of the first steps in learning about this treatment. Additionally, patients who can become pregnant need to use effective birth control during the treatment and for six months afterward. If you think you might qualify and are interested in joining, please consider discussing it with your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Willing to sign the informed consent form and follow the requirements specified in the protocol.
• • 2. Aged 18 to 75 (including 18 and 75), both genders.
• • 3. BMI ≥17
• • 4. Life expectancy ≥ 12 weeks.
• • 5. Patients with EGFR-positive advanced or metastatic solid tumors, including non-small cell lung cancer (NSCLC), squamous cell carcinoma of head and neck (SCCHN), and nasopharyngeal carcinoma (NPC).
• • 6. EGFR-positive determined by immunohistochemistry (except NSCLC, SCCHN and NPC).
• • 7. Patients must have measurable lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST v1.1).
• • 8. The score of ECOG for performance status is 0 or 1.
• • 9. No severe cardiac dysfunction.
• • 10. Acceptable liver, renal, and hematologic function.
• • 11. Patients with childbearing potential must use effective contraception during the treatment and for 6 months after the last dose of treatment.
• Exclusion Criteria:
• • 1. History of hypersensitivity to any component of the investigational product.
• • 2. Prior treatment with chemotherapy, biological therapy, immunotherapy, radiotherapy, investigational drugs, attenuated live vaccines, immunomodulators, CYP3A4 inhibitors/inducers, antibody-drug conjugates, Received major surgery without complete recovery, etc.
• • 3. Treatment with MMAE/MMAF ADC drugs
• • 4. Central nervous system metastasis.
• • 5. Toxic reaction or abnormal value of laboratory test caused by previous anti-tumor treatment ≥ 2 (CTCAE v5.0)
• • 6. Presence of peripheral neuropathy ≥ Grade 2.
• • 7. Liver function Child Pugh Grade B or Grade C。
• • 8. Pleural and peritoneal effusion or pericardial effusion with clinical symptoms requiring drainage.
• • 9. Poorly controlled systemic diseases (hypertension and hyperglycemia, etc.)
• • 10. Evidence of active infection of hepatitis B, hepatitis C or HIV.
• • 11. Patients with poorly controlled heart diseases
• • 12. History of ophthalmic abnormalities.
• • 13. History of severe skin disease requiring oral or intravenous therapy.
• • 14. History of interstitial pneumonia, radiation pneumonia, severe chronic obstructive pulmonary disease, severe pulmonary insufficiency, symptomatic bronchospasm, etc.
• • 15. Active, known or suspected autoimmune disease or drug related immune disease or the disease history within the past 2 years.
• • 16. The patient is using immunosuppressant or systemic hormone therapy.
• • 17. Patients with any past arteriovenous bleeding within 3 months or current history of coagulation disorder.
• • 18. Any clinically significant VTE occurred within 6 months.
• • 19. Received allogeneic tissue/solid organ transplantation.
• • 20. Inoculate live vaccine within 30 days before the first dose.
• • 21. Patients with a positive serum pregnancy test or who are breast-feeding or who do not agree to take adequate contraceptive measures during the treatment and for 180 days after the last dose of study treatment.
• • 22. History of other primary malignant tumor diseases.
• • 23. Investigator considers which not suitable to participate in the clinical trial