ST-segment Elevation Not Associated With Acute Cardiac Necrosis (LESTONNAC)

Launched by IDOVEN 1903 S.L. · Jan 9, 2023

Keywords

ClinConnect Summary

The LESTONNAC clinical trial is studying patients who experience chest pain and have a specific heart electrical pattern called ST segment elevation (STE). This pattern usually indicates a heart problem, but the trial is investigating whether some patients with STE may not have severe blockages in their coronary arteries or heart damage. The goal is to improve how doctors use artificial intelligence (AI) to analyze heart tests (electrocardiograms) to better differentiate between patients who need urgent treatment and those who might have a different cause for their symptoms.

To participate in this trial, individuals must be at least 18 years old and have chest pain or related symptoms. They should show STE on their heart test before receiving emergency treatment. However, those with certain heart conditions or serious anemia will not be eligible. Participants will have their heart tests analyzed both manually and with AI to see how well this technology can help in diagnosing their condition. The trial is currently active but not recruiting new patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age≥18 years.
• • Chest pain or symptoms suggestive of myocardial ischemia.
• • STE at point J in the12-lead electrocardiogram prior to activation of the infarction code in two contiguous leads ≥0.1 mV, in V2 and V3 ≥0.2 mV.
• • Signature of informed consent.
• Exclusion Criteria:
• • Left bundle branch block.
• • Acute cardiac necrosis in the absence of significant epicardial coronary artery stenosis \>70% (vasospasm, takotsubo stress cardiomyopathy, myocarditis, coronary artery dissection, acute myocardial infarction without obstructive coronary lesions - MINOCA).
• • STE≤0.1 mV with pathologic Q wave suggestive of previous chronic infarction.
• • Severe anemia (hemoglobin \<8.0 g/dl).