Correlation of Perioperative Brain Metabolites With Postoperative Delirium in Elderly Oral Craniomaxillofacial Surgery Patients

Launched by SHANGHAI NINTH PEOPLE'S HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY · Jan 12, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating how changes in brain chemistry before and after surgery may relate to a condition called postoperative delirium (POD) in older patients. POD is a common complication where patients experience confusion and difficulty thinking clearly after surgery, especially in those over 65. The researchers want to understand if certain brain metabolites (substances produced during metabolism) change during the perioperative period (the time surrounding surgery) and if these changes are linked to the development of POD.

To participate in this study, individuals must be between 65 and 90 years old and scheduled for specific oral and maxillofacial surgeries using general anesthesia. They should be in good health overall, as determined by their doctor. Participants will undergo a non-invasive brain scan to measure their brain metabolites before and after surgery, and they will also be assessed for any signs of delirium post-surgery. This research aims to improve our understanding of how to better manage the brain health of elderly patients undergoing surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The ASA grade of the subject is Ⅰ - Ⅲ;
• • 65-90 years old;
• • Oral craniomaxillofacial surgery under combined general anesthesia
• Exclusion Criteria:
• • The following medical devices have been installed in the body or are to be installed or implanted in the hospital: various cardiac pacemakers; Metal implants (non titanium), ferromagnetic vascular clips in the body
• • The patient is left-handed;
• • Patients with claustrophobia;
• • People with vision and hearing impairment, illiterate or difficult to communicate;
• • The operation plan includes patients with tracheotomy or postoperative catheterization;
• • Refusing to sign the clinical trial consent form.