A Clinical Study in Children With Heterozygous Familial Hypercholesterolemia (HeFH) Aged 6 to 17 Treated Once Daily With Bempedoic Acid Oral Dosing (CLEAR Path 1)

Launched by ESPERION THERAPEUTICS, INC. · Jan 12, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a medication called bempedoic acid to see how well it works and how safe it is for children aged 6 to 17 who have a condition known as heterozygous familial hypercholesterolemia (HeFH), which causes high cholesterol levels. The researchers want to find out how the body processes the medication and how it affects cholesterol levels over time. The trial is currently looking for participants, and they will receive the medication once a day.

To be eligible for this trial, children must be between 6 and 17 years old and have a diagnosis of HeFH. They should also be on stable cholesterol-lowering treatments and have a specific level of bad cholesterol (LDL-C) in their blood. However, children with more severe forms of high cholesterol or certain health conditions, like diabetes, cannot participate. If they join the study, participants will be closely monitored to ensure their safety and track how well the medication works. This trial could help improve treatment options for children with high cholesterol in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participant's parent(s)/guardian(s) must be willing to provide written informed consent and the participant must provide informed assent before any study-specific procedures are performed;
• • Participant must be aged 6-17 years old and willing to swallow tablets;
• • Participant must weigh at least 16 kilograms (kg);
• * Participant must have a diagnosis of HeFH prior to receiving the first dose of study medication at Treatment Visit T1 per Make Early Diagnosis to Prevent Early Deaths project (MEDPED) criteria by meeting at least one of the following clinical criteria:
• • 1. Documented diagnosis of HeFH determined by positive genetic testing; or
• 2. Documented LDL-C or TC meeting one or more of the following criteria:
• • i. LDL-C \>200 milligrams per deciliter (mg/dL) (5.2 millimole per liter \[mmol/L\]) or TC \>270 mg/dL (7.0 mmol/L), with no first- second- or third-degree relative with documented FH diagnosis (general population); or ii. LDL-C \>155 mg/dL (4.0 mmol/L) or TC \>220 mg/dL (5.7 mmol/L), and also having a first-degree relative with documented familial hypercholesterolemia (FH) diagnosis; or iii. LDL-C \>165 mg/dL (4.3 mmol/L) or TC \>230 mg/dL (5.9 mmol/L), and also having a second-degree relative with documented FH diagnosis; or iv. LDL-C \>170 mg/dL (4.4 mmol/L) or TC \>240 mg/dL (6.2 mmol/L), and also having a third-degree relative with documented FH diagnosis
• * Current treatment with approved stable lipid-modifying therapy (LMT), including an optimal dose of statin with or without other LMT(s), at stable dose for at least 4 weeks prior to Treatment Visit T1 (6 weeks for fibrates; however, gemfibrozil is not allowed in participants taking a statin as per coadministration instructions defined in the statin label). Participants must remain on that stable dose throughout the duration of the trial. Optimal dose of statin will be determined by the investigator using their medical judgment and available sources, including the participant's self-reported history of LMT. A participant's optimal dose of statin is defined as meeting one of the following criteria:
• • 1. the highest approved dose of statin prescribed for the age of the participant based on regional practice or local guidelines; or
• • 2. less than the highest approved dose of statin, including no statin, prescribed for the age of the participant based on regional practice or local guidelines (including no statin) if: i. the participant has previously taken 2 or more statin therapies at any dose and not able to tolerate or unresponsive due to their mutations (null); or ii. the participant has previously taken 1 or more statin therapies at any dose and is unwilling to attempt another statin at any dose or advised by a physician to not attempt another statin at any dose.
• • 3. Participant/parent and investigator attestation to the participant's unwillingness to attempt and/or physician advice to not attempt additional statin therapy will be recorded.
• Exclusion Criteria:
• • Participant has a diagnosis of homozygous familial hypercholesterolemia (HoFH) or compound HeFH;
• • Participant has a fasting triglyceride (TG) level ≥400 mg/dL (4.5 mmol/L);
• • Participant has uncontrolled hypothyroidism, including a value for thyroid-stimulating hormone (TSH) \< lower limit of normal (LLN) or \>1.5 × the upper limit of normal (ULN);
• * Participant has liver disease or dysfunction, including:
• • 1. positive serology for hepatitis B surface antigen (HBsAg) and/or hepatitis C virus antibodies (HCV-AB), or
• • 2. serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) value ≥2 × ULN and/or serum total bilirubin (TB) value ≥2 × ULN. If the serum TB value is ≥1.2 × ULN, a reflex indirect (unconjugated) bilirubin will be obtained and, if consistent with Gilbert's disease or if the participant has a history of Gilbert's disease, the participant may be enrolled in the study.
• • Participant has renal dysfunction or glomerulonephritis, including an estimated glomerular filtration rate (eGFR) \<75 milliliters/minute/1.73 square meter (mL/min/1.73 m\^2).
• • Other protocol defined inclusion and exclusion criteria.