Clinical Impact of Thoracic Scanographic Characteristics of Hematologic Malignancy Patients

Launched by UNIVERSITY HOSPITAL, TOULOUSE · Jan 12, 2023

Keywords

ClinConnect Summary

This clinical trial is studying patients with certain blood cancers who are experiencing symptoms related to a condition called mediastinal mass syndrome (MMS). MMS can happen when a mass in the middle of the chest puts pressure on nearby organs, leading to various symptoms like trouble breathing or issues with blood vessels. The trial aims to gather information about how these patients are diagnosed and treated, especially those who are admitted to the Intensive Care Unit (ICU) either for the first time or during a relapse of their cancer.

To participate in the trial, patients must have a blood cancer and show symptoms of MMS, and they need to be admitted to the ICU for their symptoms. They should have had a chest CT scan within a specific timeframe after receiving a certain amount of steroid treatment. The researchers hope to learn more about the best ways to manage these patients quickly and safely. Participants can expect to undergo tests and procedures to help doctors understand their condition better, and their experiences will contribute valuable information to improve future care for others facing similar challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Hematologic malignancy at diagnosis or relapse
• • Symptomatic mediastinal mass syndrome
• • Admission to the ICU, Continuous Medical Surveillance (CMS) or Intensive Care (IC) for symptomatology related to MMS
• • Chest CT (after maximum 48 hours of corticosteroid therapy (1mg/kg/ Prednisone equivalent), maximum 15 days before and 5 days after admission to ICU)
• • Maximum administration of corticosteroid therapy 48 hours before admission to the ICU (maximum 1mg/kg/ Prednisone equivalent)
• • No prior pleural or pericardial drainage
• • Study period: 01/01/2014 - 31/12/2021 (8 years)
• Exclusion Criteria:
• • No diagnosis of hematologic malignancy
• • Diagnosis of solid benign or malignant tumor
• • No mediastinal mass syndrome
• • No admission to ICU/CMS
• • No chest CT scan meeting inclusion criteria
• • Administration of corticosteroids for more than 48 hours prior to admission to the ICU and/or prior to chest CT
• • Lack of social security affiliation.