Novel Treatment for Dental Ankylosis

Launched by RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY · Jan 14, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring new treatment methods for a dental condition called dental ankylosis, where a tooth becomes fused to the bone, preventing normal growth and development in the jaw. The study aims to find out if one or two innovative approaches can help improve the situation for patients aged 6 to 30 who have been diagnosed with either a baby tooth or a certain type of permanent tooth that is mildly to moderately affected by ankylosis.

To be eligible for this trial, participants must be willing to follow the study guidelines and provide informed consent. They should be able to speak English and have a clinically diagnosed case of dental ankylosis, which will be confirmed through specific dental examinations. If someone joins the study, they can expect to be closely monitored during the treatment process, which may involve orthodontic techniques. Importantly, the trial is currently recruiting participants, and it’s a chance for individuals facing this dental issue to contribute to finding potential solutions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Full informed consent and/or informed assent (minors)
• • Be willing and able to comply with all study requirements
• • Male or female
• • Aged 6-30
• • Clinically diagnosed to have either an ankylosed deciduous tooth or a non-third molar mildly- to moderately- ankylosed permanent tooth, and with crown partially visible in the oral cavity. Clinical diagnosis of ankylosis includes the following factors: dental trauma history, infra-eruption with no apparent mechanical obstruction or other cause, contralateral tooth in occlusal contact for over one year, decreased alveolar bone height, no or reduced tooth mobility, and x-ray or cone-beam computer tomography (CBCT) imaging indications of an obliterated PDL space. Ultimately, the diagnosis will be confirmed by lack of tooth movement discovered during orthodontic treatment or when subjected to a heavy force through our study (Phelan M K, et al. 1990).
• • English speaking (primary language or fluent)
• Exclusion Criteria:
• • Severe and extensive ankylosis of permanent teeth as diagnosed through CBCT
• • Primary failure of eruption with previous orthodontic treatment
• • Any systemic disorders particularly those affecting bleeding or skeletal health
• • Any systemic medications
• • Any mental or developmental disorders that affect patient understanding or compliance
• • Allergic to our local anesthetic drug
• • Can pass an infectious disease to someone else right now (e.g., having a flu)
• • Is pregnant
• • Has a history of smoking
• • Have not reached the age of 6 or older than age of 30
• • Not cooperative enough during dental examinations
• • The dentist finds out that he/she is not able to keep the mini-implant, the brackets and the wires in place around the tooth that is being treated
• • Not fluent in English