Neural and Physiological Correlates of Psychedelic Sub-states

Launched by ROBIN CARHART-HARRIS, PHD, MA · Jan 13, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "Neural and Physiological Correlates of Psychedelic Sub-states," is exploring how the brain and body react during experiences with psilocybin, a substance found in certain mushrooms known for its psychedelic effects. The goal is to better understand these unique mental and physical states by using MRI scans on healthy volunteers while they are under the influence of psilocybin. Researchers hope that this study will pave the way for future investigations into the therapeutic potential of psilocybin and similar psychedelics.

To be eligible for this study, participants should be between 21 and 70 years old, have prior experience with psychedelics, and be in good mental and physical health. Participants will take psilocybin in four separate sessions over about 6 to 12 weeks, with breaks in between. Each session will involve lying in an MRI scanner while answering a couple of quick questions about their experience. Additionally, there will be follow-up calls after each session to discuss how participants felt. If you're interested and meet the criteria, this could be an exciting opportunity to contribute to important research in this field!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Have had previous experiences with psychedelic substances
• • Mentally and physically healthy
• • Have had prior experiences with MRI machines (optional but preferred)
• • Flexible schedule- able to commit to scans once or twice per week for 4 weeks in a row
• • Are between 21 and 70 years of age
• • Are fluent in speaking and reading English
• • Can swallow pills/capsules
• • If able to become pregnant, must be non-lactating, have a negative pregnancy test at study entry and prior to each Experimental Session and must agree to an adequate form of birth control and contraception over the course of the study. Adequate forms of birth control or contraception include intrauterine device (IUD), injected, implanted, intravaginal, or transdermal hormonal methods, abstinence, oral hormones plus a barrier contraception, vasectomized sole partner, or double barrier contraception. Two forms of contraception are required with any barrier method or oral hormones (i.e. condom plus diaphragm, condom or diaphragm plus spermicide, oral hormonal contraceptives plus spermicide or condom). Not of childbearing potential is defined as documented hysterectomy, bilateral salpingectomy, bilateral oophorectomy, and/or tubal ligation), permanently sterile by medical device such as Essure, postmenopausal, or male by birth. Contraception applies to males as well as females and male participants must not be planning sperm donation within the study period.
• • Able and willing to provide informed consent
• • Able and willing to use computers and tablets or phones to enter electronic data
• • Agree to inform the investigators within 48 hours of any new or changed medical conditions.