Cardiac Power Output in Cardiogenic Shock Patients

Launched by UNIVERSITY OF CHICAGO · Jan 17, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how the heart's ability to pump blood, known as myocardial reserve, might help predict how well patients with heart failure do in the long run. Specifically, it focuses on patients experiencing cardiogenic shock, a serious condition where the heart can't pump enough blood to meet the body's needs. The study is currently recruiting participants aged 18 and older who have a weakened heart (with a specific measurement of how well the heart pumps, known as LVEF, of 35% or lower) and are being evaluated for advanced heart treatments.

If you or a loved one qualifies, you can expect to undergo a special test called right heart catheterization (RHC), which helps doctors measure how well your heart and blood vessels are working. This trial is important because understanding the heart's reserve could lead to better treatment options for those with severe heart issues. It's essential that participants do not have certain conditions, like severe coronary artery disease or recent heart attacks, to ensure their safety during the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. LVEF ≤ 40%
• 2. Referred for RHC for:
• • 1. Evaluation for advanced heart failure therapies, including LVAD, OHT, temporary or long-term inotrope therapy, or counter-pulsation (temporary or long-term with NuPulse device OR
• • 2. Accurate assessment of invasive hemodynamics due to worsening clinical status, OR
• • 3. Assessment of myocardial recovery for consideration of LVAD or counter-pulsation (temporary IABP or long-term with NuPulse device) decommissioning or removal OR
• • 4. Assessment of cardiac function and valvular abnormalities prior to planned valvular surgery for MR or AI
• • 3. Estimated glomerular filtration rate (eGFR) ≥ 30 ml/min/1.73 m2
• • 4. Age ≥ 18 years-old
• • 5. Intent for admission based on RHC data
• Exclusion Criteria:
• • 1. eGFR \< 30 ml/min/1.73 m2
• • 2. Severe, non-revascularized coronary artery disease
• • 3. Concurrent acute coronary syndrome
• • 4. Age \< 18 years-old
• • 5. History of significant ventricular arrhythmia without an ICD