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Search / Trial NCT05702034

A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE

Launched by JANSSEN RESEARCH & DEVELOPMENT, LLC · Jan 19, 2023

Trial Information

Current as of July 23, 2025

Recruiting

Keywords

ClinConnect Summary

The LIBREXIA-STROKE trial is studying a new medication called milvexian to see if it can help prevent another ischemic stroke in people who have recently experienced one or a high-risk transient ischemic attack (TIA), which is sometimes called a "mini-stroke." In this study, participants will be randomly assigned to receive either milvexian or a placebo (a substance with no active medication) to compare how well each option works.

To be eligible for this trial, participants must have had an ischemic stroke or a TIA within the last 48 hours and meet specific health criteria, such as having a certain level of neurological symptoms and being willing to follow the trial guidelines. Participants will be monitored closely and can expect to adhere to some lifestyle restrictions during the study. It's important to note that women in the study must not be pregnant or planning to become pregnant for a short time after the study medication. If you or a loved one are interested in participating, please talk to a healthcare provider for more information.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Ischemic Stroke: a neurological deficit attributable to an acute brain infarction and national institute of health stroke score scale (NIHSS) score less than or equal to (\<=) 7 and at least 1 of the following: persistent signs or symptoms of the ischemic event at the time of randomization, or acute, ischemic brain lesion determined by standard-of-care neuroimaging, or participant underwent thrombolysis or thrombectomy, or transient ischemic attack (TIA): acute onset neurological deficit attributable to focal ischemia of the brain by history or examination, with complete symptom resolution of the deficit and no brain infarction on neuroimaging (example, computed tomography (CT) scan or magnetic resonance imaging (MRI), performed as part of standard medical practice), and ABCD2 Score greater than or equal to (\>=) 6
  • Participants will be randomized as soon as possible after determining eligibility and within 48 hours of onset of event.
  • Current or planned antiplatelet treatment per international and/or local guidelines. If acetyl salicylic acid (ASA) is used, it will be limited to low dose (75 to 100 milligrams (mg)/day). Loading dose of antiplatelet agents (including ASA) are allowed per standard-of-care
  • A female participant must agree not to be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half lives) after the last dose of study intervention
  • Willing and able to adhere to the lifestyle restrictions specified in this protocol
  • Exclusion Criteria:
  • Prior history of intracranial hemorrhage except subarachnoid hemorrhage greater than (\>) 1 year prior with adequate treatment
  • The index stroke or TIA is considered to have a cardio-embolic etiology based on local standard-of-care investigations and for which guidelines recommend anticoagulation
  • The index stroke or TIA considered to have another known cause, not related to athero-thrombotic sources (treatment of acute stroke trial \[TOAST\] Other Determined Etiology), based on local standard-of-care investigations
  • Increased risk of bleeding, including clinically significant bleeding within the previous 3 months or known bleeding diathesis or known activated partial thromboplastin time (aPTT) prolongation or spinal cord hemorrhage or retinal hemorrhage
  • Current active liver disease, eg, acute hepatitis, known cirrhosis, including participants receiving antiviral treatment for hepatitis
  • Known allergies, hypersensitivity, or intolerance to milvexian or its excipients

About Janssen Research & Development, Llc

Janssen Research & Development, LLC, a subsidiary of Johnson & Johnson, is a leading pharmaceutical company dedicated to advancing innovative therapies in multiple therapeutic areas, including oncology, immunology, neuroscience, infectious diseases, and cardiovascular health. With a strong commitment to scientific excellence and patient-centered research, Janssen leverages cutting-edge technology and collaborative partnerships to drive the development of transformative treatments. The company is focused on addressing unmet medical needs through rigorous clinical trials and a robust pipeline, aiming to improve health outcomes and enhance the quality of life for patients worldwide.

Locations

Evanston, Illinois, United States

Laquenexy, , France

Ciudad Autonoma De Buenos Aires, , Argentina

Cordoba, , Argentina

Cordoba, , Argentina

Kobe Shi, , Japan

Katowice Ochojec, , Poland

Lisboa, , Portugal

Aurora, Colorado, United States

Pensacola, Florida, United States

Silver Spring, Maryland, United States

La Mesa, California, United States

West Palm Beach, Florida, United States

Mons, , Belgium

Campo Largo, , Brazil

Rijeka, , Croatia

Muenchen, , Germany

Iloilo, , Philippines

Lipa City, , Philippines

San Fernando, , Philippines

Malaga, , Spain

Lincoln, , United Kingdom

Chia Yi City, , Taiwan

Hualien, , Taiwan

Thessaloniki, , Greece

New Delhi, , India

Surat, , India

Varanasi, , India

Tel Aviv, , Israel

Nishinomiya Shi, , Japan

Toyohasi Shi, , Japan

Tongaat, , South Africa

Worcester, , South Africa

Eugene, Oregon, United States

Changchun, Jilin, China

Dalian, Liaoning, China

Pingxiang, Jiangxi, China

Shenyang, Liaoning, China

Shijiazhuang, Hebei, China

Osaka, , Japan

Temple Terrace, Florida, United States

Bern, , Switzerland

Dundee, , United Kingdom

York, , United Kingdom

Changsha, , China

Chengdu, , China

Luoyang, , China

Pingxiang, , China

Shantou, , China

Besançon Cedex, , France

Laquenexy, , France

Limoges, , France

Kawasaki City, , Japan

Sapporo Shi, , Japan

Incheon, , Korea, Republic Of

Seoul, , Korea, Republic Of

Uijeongbu Si, , Korea, Republic Of

Chicago, Illinois, United States

Barcelona, , Spain

Curitiba, , Brazil

Surat, , India

Tokyo, , Japan

New Lambton Heights, , Australia

Hamburg, , Germany

Pune, , India

Fukuoka Shi, , Japan

Wejherowo, , Poland

Durban, , South Africa

Istanbul, , Turkey

Izmir, , Turkey

Leuven, , Belgium

Athens, , Greece

Bursa, , Turkey

Izmir, , Turkey

Newark, New Jersey, United States

Antwerpen, , Belgium

Zagreb, , Croatia

Kasugai Shi, , Japan

Kortrijk, , Belgium

Santa Monica, California, United States

Nanyang, Henan, China

Tonghua, Jilin, China

Yantai, Shandong, China

Torrance, California, United States

Budapest, , Hungary

Bikaner, , India

Dzialdowo, , Poland

Jingdezhen, , China

Indianapolis, Indiana, United States

Niagara Falls, Ontario, Canada

Shenyang, , China

Praha 6, , Czechia

Kumamoto, , Japan

Sungai Buloh, , Malaysia

Tiwi, , Australia

Toyota Shi, , Japan

Ahmedabad, , India

Plovdiv, , Bulgaria

Santiago, , Chile

Nashik, , India

Komoro Shi, , Japan

Preston, , United Kingdom

São Paulo, , Brazil

Roma, , Italy

Asheville, North Carolina, United States

Washington, District Of Columbia, United States

Vac, , Hungary

Malmoe, , Sweden

Ishikawa, , Japan

Linfen, Shanxi, China

Sejong Si, , Korea, Republic Of

Houston, Texas, United States

Cordoba, , Spain

Cordoba, , Argentina

New Westminster, British Columbia, Canada

Beijing, , China

Olomouc, , Czechia

Brest Cedex, , France

Tokyo, , Japan

Tsukuba City, , Japan

Kunming, , China

Urumchi, , China

Wuxi, , China

Banska Bystrica, , Slovakia

Tainan, , Taiwan

Chiangmai, , Thailand

Nashville, Tennessee, United States

Matsubara Shi, , Japan

Yonezawa Shi, , Japan

Pikeville, Kentucky, United States

Cordoba, , Spain

Mangalore, , India

Thiruvananthapuram, , India

Beijing, , China

Osaka, , Japan

East Kilbride, , United Kingdom

Bronx, New York, United States

Brasilia, , Brazil

Changchun, , China

Changsha, , China

Lanzhou, , China

Jinan, Shandong, China

Nanyang, , China

Thessaloniki, , Greece

Wenzhou, , China

Shimonoseki Shi, , Japan

Písek, , Czechia

Budapest, , Hungary

Ankara, , Turkey

Skarzysko Kamienna, , Poland

St. Gallen, , Switzerland

Kurume Shi, , Japan

Paris, , France

Vishakhapatnam, , India

Pune, , India

Lublin, , Poland

Salamanca, , Spain

Joliet, Illinois, United States

Rockford, Illinois, United States

Louisville, Kentucky, United States

Bethesda, Maryland, United States

Grand Rapids, Michigan, United States

Fayetteville, Arkansas, United States

Saint Louis, Missouri, United States

Berkeley, California, United States

San Diego, California, United States

San Diego, California, United States

Thousand Oaks, California, United States

Newark, Delaware, United States

Bradenton, Florida, United States

Delray Beach, Florida, United States

Saint Louis, Missouri, United States

Camden, New Jersey, United States

Brooklyn, New York, United States

New York, New York, United States

Sleepy Hollow, New York, United States

Miami, Florida, United States

Miami, Florida, United States

Cleveland, Ohio, United States

Portland, Oregon, United States

Portland, Oregon, United States

Allentown, Pennsylvania, United States

Paoli, Pennsylvania, United States

Chattanooga, Tennessee, United States

Nashville, Tennessee, United States

Austin, Texas, United States

Port Charlotte, Florida, United States

Dallas, Texas, United States

Sarasota, Florida, United States

Glenview, Illinois, United States

Dendermonde, , Belgium

Edegem, , Belgium

Gent, , Belgium

El Paso, Texas, United States

Brasília, , Brazil

Fort Worth, Texas, United States

Seattle, Washington, United States

Buenos Aires, , Argentina

Buenos Aires, , Argentina

Ciudad Autonoma Buenos Aires, , Argentina

Ciudad Autonoma De Buenos Airess, , Argentina

Ciudad De Buenos Aires, , Argentina

Curitiba, , Brazil

Niteroi, , Brazil

Porto Alegre, , Brazil

Cordoba, , Argentina

Mar Del Plata, , Argentina

Mendoza, , Argentina

Salta, , Argentina

Bankstown, , Australia

Sao Jose Do Rio Preto, , Brazil

Campbelltown, , Australia

Sao Paulo, , Brazil

São Paulo, , Brazil

Stara Zagora, , Bulgaria

Midland, , Australia

Mississauga, Ontario, Canada

Concepcion, , Chile

Santiago, , Chile

St Leonards, , Australia

Modling, , Austria

Santiago, , Chile

Arlon, , Belgium

Talcahuano, , Chile

Temuco, , Chile

Baotou, , China

Brussels, , Belgium

Chongqing, , China

Beijing, , China

Dalian, , China

Changzhou, , China

Dalian, , China

Daqing, , China

Dongguan, , China

Guangzhou, , China

Guangzhou, , China

Usti Nad Labem, , Czechia

Aarhus, , Denmark

Hangzhou, , China

Copenhagen Nv, , Denmark

Copenhagen, , Denmark

Herlev, , Denmark

Odense C, , Denmark

Hefei, , China

Tallinn, , Estonia

Tartu, , Estonia

Lappeenranta, , Finland

Huhehaote, , China

Jiaozuo, , China

Nanjing, , China

Aix En Provence Cedex 01, , France

Le Kremlin Bicetre Cedex, , France

Le Mans Cedex 9, , France

Nice Cedex 1, , France

Rennes Cedex 09, , France

Bremen, , Germany

Deggendorf, , Germany

Dresden, , Germany

Guenzburg, , Germany

Hannover, , Germany

Muenster, , Germany

New Territories, , Hong Kong

Budapest, , Hungary

Budapest, , Hungary

Budapest, , Hungary

Vac, , Hungary

Amritsar, , India

Hyderabad, , India

Hyderabad, , India

Lucknow, , India

Mysore, , India

New Delhi, , India

Yerushalayim, , Israel

Aichi, , Japan

Pingxiang, , China

Aki Gun, , Japan

Chiba Shi, , Japan

Chiba, , Japan

Chikushino Shi, , Japan

Qingdao, , China

Shandong, , China

Shenyang, , China

Tai'an, , China

Fukuoka, , Japan

Fukuoka, , Japan

Taizhou, , China

Wuxi, , China

Xi'an, , China

Zabok, , Croatia

Chomutov, , Czechia

Praha 10, , Czechia

Nagano Shi, , Japan

Praha 4, , Czechia

Gyeonggi Do, , Korea, Republic Of

Tokyo, , Japan

Aguascalientes, , Mexico

Vila Real, , Portugal

Arad, , Romania

Oradea, , Romania

Levoca, , Slovakia

Liptovsky Mikulas, , Slovakia

Lucenec, , Slovakia

Nitra, , Slovakia

Sabadell, , Spain

Salamanca, , Spain

Zaragoza, , Spain

Stockholm, , Sweden

Ciudad De Mexico, , Mexico

Culiacan, , Mexico

Mexico, , Mexico

Bern, , Switzerland

Monterrey, , Mexico

Puebla, , Mexico

Christchurch, , New Zealand

Hamilton, , New Zealand

Genève, , Switzerland

Baguio City, , Philippines

Kaohsiung, , Taiwan

Constanta, , Romania

Margate, , United Kingdom

Ho Chi Minh, , Vietnam

Davao City, , Philippines

Ilocos Sur, , Philippines

Iloilo City, , Philippines

Manila, , Philippines

Warszawa, , Poland

Warszawa, , Poland

Lisboa, , Portugal

Long Beach, California, United States

Chelmie, , Poland

Detroit, Michigan, United States

Loures, , Portugal

Pragal, , Portugal

Vila Nova De Gaia, , Portugal

Ludhiana, , India

Warszawa, , Poland

Turku, , Finland

Sacramento, California, United States

Sarasota, Florida, United States

Boston, Massachusetts, United States

East Lansing, Michigan, United States

Cordoba, , Argentina

Camperdown, , Australia

Belo Horizonte, , Brazil

Porto Alegre, , Brazil

Montana, , Bulgaria

Sofia, , Bulgaria

Guangzhou, , China

Hangzhou, , China

Lanzhou, , China

Verona, , Italy

Shijiazhuang, , China

ålborg, , Denmark

Nanjing, , China

Tallinn, , Estonia

Hus, , Finland

Kistarcsa, , Hungary

Kisvarda, , Hungary

Miskolc, , Hungary

Dunaujvaros, , Hungary

Vilnius, , Lithuania

Jaipur, , India

Kuala Lumpur, , Malaysia

Bucuresti, , Romania

Kragujevac, , Serbia

Ludhiana, , India

Bratislava, , Slovakia

Oakland, California, United States

Fukuoka, , Japan

Everett, Washington, United States

Cordoba, , Argentina

Palo Alto, California, United States

Torrance, California, United States

Naharya, , Israel

Lecce, , Italy

Nagoya Shi, , Japan

Sao Paulo, , Brazil

Sofia, , Bulgaria

Okayama Shi, , Japan

Fitzroy, , Australia

Kosice, , Slovakia

Levice, , Slovakia

Petrzalka, , Slovakia

Albacete, , Spain

Herning, , Denmark

Omaha, Nebraska, United States

Gifu, , Japan

Adelaide, , Australia

Randwick, , Australia

Osaka Shi, , Japan

Lethbridge, Alberta, Canada

Sofia, , Bulgaria

Federal, , Argentina

Klagenfurt, , Austria

Santiago, , Chile

Marseille Cedex 05, , France

Tatabanya, , Hungary

Baoji, , China

Fukuoka, , Japan

Irvine, California, United States

Bangalore, , India

Modena, , Italy

Buenos Aires, , Argentina

San Francisco, California, United States

Greeley, Colorado, United States

Caba, , Argentina

Ciudad Autonoma Buenos Aires, , Argentina

Changchun, , China

Nanchang, , China

Liverpool, , Australia

Botucatu, , Brazil

Nanyang, , China

N.T., , Hong Kong

Kolkata, , India

Foligno, , Italy

Kumamoto, , Japan

Kure Shi, , Japan

Nagasaki Shi, , Japan

Tokyo, , Japan

Toyoake, , Japan

Breda, , Netherlands

Debrecen, , Hungary

Coimbatore, , India

Fort Wayne, Indiana, United States

Dortmund, , Germany

Chenzhou, , China

Gurgaon, , India

Urayasu Shi, , Japan

Nashik, , India

New Delhi, , India

Targu Mures, , Romania

Taoyuan County, , Taiwan

Bangkok, , Thailand

Lucenec, , Slovakia

Halifax, , United Kingdom

Abington, Pennsylvania, United States

Changsha, , China

Hanoi, , Vietnam

Qiqihaer, , China

Taiyuan, , China

Córdoba, , Argentina

Gyor, , Hungary

Gwangju, , Korea, Republic Of

Guimarães, , Portugal

Wirral, , United Kingdom

Launceston, , Australia

Edmonton, Alberta, Canada

Hatsukaichi, , Japan

Kyoto Shi, , Japan

Nis, , Serbia

Norfolk, Virginia, United States

Lake Success, New York, United States

Munster, Indiana, United States

Fortaleza, , Brazil

Nashville, Tennessee, United States

Perpignan, , France

Castro Valley, California, United States

Hyderabad, , India

Dallas, Texas, United States

Kasuga Shi, , Japan

Hyderbad, , India

Kirkland, Washington, United States

Ciudad Autonoma Buenos Aires, , Argentina

Herston, , Australia

Greensboro, North Carolina, United States

Hidaka, , Japan

Boise, Idaho, United States

Zagreb, , Croatia

Ho Chi Minh, , Vietnam

Ramat Gan, , Israel

Kota Bharu, , Malaysia

Toulouse Cedex 9, , France

Aguascalientes, , Mexico

Owosso, Michigan, United States

Zagreb, , Croatia

Shenyang, , China

Martin, , Slovakia

Bridgeton, Missouri, United States

Tonghua, , China

Houston, Texas, United States

Wels, , Austria

Plovdiv, , Bulgaria

Joinville, , Brazil

Lexington, Kentucky, United States

Baltimore, Maryland, United States

Vancouver, British Columbia, Canada

Jihlava, , Czechia

Sendai Shi, , Japan

Xian, , China

Yangzhou, , China

Chengdu, , China

Mesa, Arizona, United States

Burlingame, California, United States

Beer Sheva, , Israel

Portland, Oregon, United States

Erie, Pennsylvania, United States

Spokane, Washington, United States

Sao Jose Do Rio Preto, , Brazil

Morelia, , Mexico

Huhehaote, , China

Split, , Croatia

Vitoria, , Brazil

Dongguan, , China

Olomouc, , Czechia

Poitiers, , France

Goettingen, , Germany

Chennai, , India

Sacramento, California, United States

Kaili, , China

Wenzhou, , China

Bern, , Switzerland

Fukuoka, , Japan

London, , United Kingdom

Taunton, , United Kingdom

Erie, Pennsylvania, United States

Philadelphia, Pennsylvania, United States

Nashville, Tennessee, United States

Nashville, Tennessee, United States

Campinas, , Brazil

Los Alamitos, California, United States

Criciúma, , Brazil

Ijuí, , Brazil

São José Do Rio Preto, , Brazil

Las Condes, , Chile

Sacramento, California, United States

Coeur D'alene, Idaho, United States

Chicago, Illinois, United States

Springfield, Illinois, United States

Clinton Township, Michigan, United States

Farmington Hills, Michigan, United States

Flint, Michigan, United States

Hackensack, New Jersey, United States

Turku, , Finland

Budapest, , Hungary

Lueneburg, , Germany

Pavia, , Italy

Fukuoka Shi, , Japan

Kitakyushu Shi, , Japan

Suita Shi, , Japan

Hyderabad, , India

Brescia, , Italy

Seoul, , Korea, Republic Of

Aguascalientes, , Mexico

Culiacan, , Mexico

Tongaat, , South Africa

Wenzhou, , China

Tauranga, , New Zealand

Yichang, , China

Haifa, , Israel

Fullerton, California, United States

Bruxelles, , Belgium

Halifax, Nova Scotia, Canada

Québec, Quebec, Canada

Essen, , Germany

Faridabad, , India

Eger, , Hungary

Bialystok, , Poland

Boleslawiec, , Poland

Bydgoszcz, , Poland

Lublin, , Poland

Olsztyn, , Poland

Warszawa, , Poland

Sakarya, , Turkey

Novi Sad, , Serbia

Glendale, California, United States

Farmington Hills, Michigan, United States

New York, New York, United States

Mission Viejo, California, United States

Ishikawa, , Japan

Katowice Ochojec, , Poland

Rybnik, , Poland

Ankara, , Turkey

Elazıg, , Turkey

Distrito Federal, , Mexico

Frankfurt, , Germany

Istanbul, , Turkey

Safed, , Israel

Tulsa, Oklahoma, United States

Changsha, , China

Philadelphia, Pennsylvania, United States

Ijui, , Brazil

Burlingame, California, United States

Istanbul, , Turkey

Sao Paulo, , Brazil

São Paulo, , Brazil

Tianjin, , China

Chicago, Illinois, United States

Springfield, Illinois, United States

Sliven, , Bulgaria

Southfield, Michigan, United States

Taizhou, , China

Ostrava Vitkovice, , Czechia

Vaasa, , Finland

Berlin, , Germany

Sofia, , Bulgaria

Berlin, , Germany

Frankfurt, , Germany

Tsukuba City, , Japan

Seongnam Si, , Korea, Republic Of

Hull, , United Kingdom

Fulda, , Germany

Sheffield, , United Kingdom

Watford, , United Kingdom

Rouen Cedex, , France

Dresden, , Germany

Vila Nova De Gaia, , Portugal

Lueneburg, , Germany

Miami, Florida, United States

Barakaldo, , Spain

Berlin, , Germany

Shanghai, , China

Quincy, Illinois, United States

Detroit, Michigan, United States

Hackensack, New Jersey, United States

Ann Arbor, Michigan, United States

Coronel Suarez, , Argentina

Bonheiden, , Belgium

Eau Claire, Wisconsin, United States

Uberaba, , Brazil

Beijing, , China

Taiyuan, , China

Taizhou, , China

Bjelovar, , Croatia

Osijek, , Croatia

Praha 6, , Czechia

Bourg En Bresse Cedex, , France

Hamburg, , Germany

Idar Oberstein, , Germany

Leipzig, , Germany

Luebeck, , Germany

Liaocheng, , China

Schleswig, , Germany

Ulm, , Germany

Athens, , Greece

Ahmedabad, , India

Anand, , India

Bangalore, , India

Cochin, , India

Varanasi, , India

Haifa, , Israel

Salgotarjan, , Hungary

Petah Tikva, , Israel

Massa, , Italy

Kyoto Shi, , Japan

Kawasaki Shi, , Japan

Yantai, , China

Staszow, , Poland

Tokyo, , Japan

Shimotsuke, , Japan

Clearwater, Florida, United States

Augusta, Georgia, United States

Houston, Texas, United States

Coimbra, , Portugal

Spisska Nova Ves, , Slovakia

New Orleans, Louisiana, United States

Baltimore, Maryland, United States

Buenos Aires, , Argentina

Winchester, Virginia, United States

Braga, , Portugal

Ribeirao Preto, , Brazil

Linfen, , China

Jinan, , China

Ioannina, , Greece

Besançon Cedex, , France

Bordeaux Cedex, , France

Brest Cedex, , France

Caen, , France

Corbeil Essonnes Cedex, , France

Ibaraki, , Japan

Budapest, , Hungary

Gryfice, , Poland

Lund, , Sweden

Incheon, , Korea, Republic Of

Valencia, , Spain

Vigo, , Spain

Madrid, , Spain

Madrid, , Spain

Madrid, , Spain

Madrid, , Spain

Girona, , Spain

Lleida, , Spain

Palma De Mallorca, , Spain

Sandanski, , Bulgaria

Changhua, , Taiwan

Bangkoknoi, , Thailand

Pathum Wan, , Thailand

Airdrie, , United Kingdom

Bury, , United Kingdom

London, , United Kingdom

London, , United Kingdom

Luton, , United Kingdom

Truro, , United Kingdom

Uppsala, , Sweden

Basel, , Switzerland

Ha Noi, , Vietnam

Ho Chi Minh, , Vietnam

Lohr Am Main, , Germany

Riga, , Latvia

Vellore, , India

Hanoi, , Vietnam

Akron, Ohio, United States

Peoria, Illinois, United States

Parkville, , Australia

Traralgon, , Australia

Wels, , Austria

Springfield, Missouri, United States

Ruse, , Bulgaria

Sofia, , Bulgaria

Vina Del Mar, , Chile

Ostrava Vitkovice, , Czechia

Poruba, , Czechia

Glostrup, , Denmark

Sofia, , Bulgaria

Lille Cedex, , France

Limoges, , France

Metz Tessy, , France

Paris, , France

Paris, , France

Sofia, , Bulgaria

Aachen, , Germany

Poitiers, , France

Fulda, , Germany

Giessen, , Germany

Berlin, , Germany

Berlin, , Germany

Hamburg, , Germany

Lecco, , Italy

Milano, , Italy

Saitama Shi, , Japan

Shimonoseki Shi, , Japan

Suita Shi, , Japan

Anyang Si, , Korea, Republic Of

Busan, , Korea, Republic Of

Seoul, Ma, Korea, Republic Of

Dresden, , Germany

Seberang Jaya, , Malaysia

Seoul, , Korea, Republic Of

Ulsan, , Korea, Republic Of

Yongin Si, , Korea, Republic Of

Lodz, , Poland

Uden, , Netherlands

Auckland, , New Zealand

Covilha, , Portugal

Krakow, , Poland

Charlotte, North Carolina, United States

Austin, Texas, United States

Liege, , Belgium

Madrid, , Spain

Paris, , France

Shizuoka Aoi Ku, , Japan

Busan, , Korea, Republic Of

Vilnius, , Lithuania

Ciudad Autonoma Buenos Aires, , Argentina

Aix En Provence Cedex 01, , France

Trencin, , Slovakia

Bloemfontein, , South Africa

Rouen Cedex, , France

Ota Ku, , Japan

Olsztyn, , Poland

Chiangmai, , Thailand

Kansas City, Kansas, United States

Frankfurt, , Germany

Kitakyushu Shi, , Japan

Heidelberg, , Australia

South Brisbane, , Australia

Ath, , Belgium

Buffalo, New York, United States

Xiamen, , China

Clermont Ferrand Cedex, , France

Jamaica, New York, United States

Columbus, Ohio, United States

Grodzisk Mazowiecki, , Poland

Johannesburg, , South Africa

Terrassa, , Spain

Hamamatsu, , Japan

Shinjuku Ku, , Japan

Erlangen, , Germany

Zaragoza, , Spain

Pleven, , Bulgaria

Garches, , France

La Roche Sur Yon, , France

N T, , Hong Kong

Tokyo, , Japan

Uwajima Shi, , Japan

Adelaide, , Australia

Rybnik, , Poland

Goyang Si, , Korea, Republic Of

Daegu, , Korea, Republic Of

Omuta Shi, , Japan

Osaka Shi, , Japan

Seoul, , Korea, Republic Of

Niteroi, , Brazil

Dupnitsa, , Bulgaria

Leipzig, , Germany

Friedrichshafen, , Germany

Lueneburg, , Germany

Nai Mueang Subdistrict Mueang, , Thailand

Leszno, , Poland

Seoul, , Korea, Republic Of

Changchun, , China

Glasgow, , United Kingdom

Royal Oak, Michigan, United States

Cincinnati, Ohio, United States

Oklahoma City, Oklahoma, United States

Udine, , Italy

Wellington, , New Zealand

Ciudad De Mexico, , Mexico

Faridkot, , India

Lisboa, , Portugal

Davao City, , Philippines

Singapore, , Singapore

Bath, , United Kingdom

Murdoch, , Australia

Cordoba, , Argentina

Sherbrooke, Quebec, Canada

Torun, , Poland

Osaka, , Japan

Tokyo, , Japan

Muang, , Thailand

Neptune, New Jersey, United States

Buenos Aires, , Argentina

Montpellier, , France

Nancy, , France

Guimaraes, , Portugal

George, , South Africa

Seoul, , Korea, Republic Of

Krakow, , Poland

Varanasi, , India

Vizianagaram, , India

Jerusalem, , Israel

Samsun, , Turkey

Turkey, , Turkey

Philadelphia, Pennsylvania, United States

Sande, , Germany

Pretoria, , South Africa

Ankara, , Turkey

Erciyes, , Turkey

Istanbul, , Turkey

Jinan, , China

Bhubaneswar, , India

Koga, , Japan

Ipoh, , Malaysia

Konya, , Turkey

Guimaraes, , Portugal

Columbia, Missouri, United States

Ribeirao Preto, , Brazil

Xiangtan, , China

Hiroshima Shi, , Japan

Cape Town, , South Africa

Criciúma, , Brazil

Gorna Oryahovitsa, , Bulgaria

Jinzhou, , China

Kawasaki City, , Japan

Haskovo, , Bulgaria

Sindelfingen, , Germany

Rosario, , Argentina

Incheon, , Korea, Republic Of

Rostock, , Germany

Weimar, , Germany

Wuerzburg, , Germany

Larissa, , Greece

Tuebingen, , Germany

Thessaloniki, , Greece

Eger, , Hungary

Thessaloniki, , Greece

Pecs, , Hungary

Belgaum, , India

Bhubaneshwar, , India

Gurgaon, , India

Bikaner, , India

Chandigarh, , India

Pune, , India

Shimla, , India

Cagliari, , Italy

Higashihiroshima Shi, , Japan

Pavia, , Italy

Ota Ku, , Japan

Rozzano, , Italy

Seoul, , Korea, Republic Of

Hachioji, , Japan

Saga, , Japan

Kitakyushu Shi, , Japan

Hiroshima Shi, , Japan

Kobe Shi, , Japan

Gangseo Gu, , Korea, Republic Of

Seoul, , Korea, Republic Of

Burbank, California, United States

Joliet, Illinois, United States

Burnsville, Minnesota, United States

Edina, Minnesota, United States

Brandon, Manitoba, Canada

Minden, , Germany

Alexandroupolis, , Greece

Athens, , Greece

Larisa, , Greece

Gubbio, , Italy

Saitama Shi, , Japan

Sendai Shi, , Japan

Daegu, , Korea, Republic Of

Seoul, , Korea, Republic Of

Fukuoka Shi, , Japan

Seoul, , Korea, Republic Of

Seoul, , Korea, Republic Of

Chiayi, , Taiwan

Stoke On Trent, , United Kingdom

Gifu, , Japan

Himeji Shi, , Japan

Hiroshima, , Japan

Kagoshima, , Japan

Serdang, , Malaysia

Cebu, , Philippines

Staszow, , Poland

Porto, , Portugal

Brasov, , Romania

Bucuresti, , Romania

Bucuresti, , Romania

Manila, , Philippines

Manila, , Philippines

Manila, , Philippines

Pasay City, , Philippines

Boca Raton, Florida, United States

Timisoara, , Romania

Pasig City, , Philippines

Belgrade, , Serbia

Sombor, , Serbia

Subotica, , Serbia

Uzice, , Serbia

Trenton, New Jersey, United States

Houston, Texas, United States

Singapore, , Singapore

Alicante, , Spain

Badalona, , Spain

Somerset West, , South Africa

Barcelona, , Spain

L'hospitalet De Llobregat, , Spain

La Coruña, , Spain

Madrid, , Spain

Santiago De Compostela, , Spain

Sevilla, , Spain

Valencia, , Spain

Valladolid, , Spain

Skövde, , Sweden

Aarau, , Switzerland

Keelung, , Taiwan

New Taipei City, , Taiwan

Taipei, , Taiwan

Ho Chi Minh, , Vietnam

Ho Chi Minh, , Vietnam

Klang, , Malaysia

Lisboa, , Portugal

Saint Louis Park, Minnesota, United States

Medicine Hat, Alberta, Canada

Sudbury, Ontario, Canada

Altenburg, , Germany

Thessaloniki, , Greece

Bangkok, , Thailand

San Luis Potosi, , Mexico

Quezon City, , Philippines

Belgaum, , India

Pietra Ligure, , Italy

Quezon, , Philippines

Anyang, , China

Ganzhou, , China

Thane, , India

Toyohasi Shi, , Japan

Vancouver, British Columbia, Canada

Thessaloniki, , Greece

Brescia, , Italy

Otahuhu, , New Zealand

Trieste, , Italy

Busan, , Korea, Republic Of

La Coruña, , Spain

Douliou City, , Taiwan

Canton, Ohio, United States

Lianyungang, , China

Nanjing, , China

Botevgrad, , Bulgaria

Toronto, Ontario, Canada

Qingdao, , China

Seoul, , Korea, Republic Of

Besancon Cedex, , France

Essen, , Germany

Kolkata, , India

Timisoara, , Romania

Trebisov, , Slovakia

La Louvière, , Belgium

Budapest, , Hungary

Reggio Emilia, , Italy

Roma, , Italy

Chiba, , Japan

Sendai Shi, , Japan

Rajkot, , India

Perugia, , Italy

Maebashi, , Japan

Ina Shi, , Japan

Chennai, , India

Mumbai, , India

Mysuru, , India

Nishinomiya Shi, , Japan

Boleslawiec, , Poland

Bydgoszcz, , Poland

Santa Maria Da Feira, , Portugal

Belgrade, , Serbia

Madrid, , Spain

Kaohsiung, , Taiwan

Redwood City, California, United States

San Nicolas, , Argentina

Sumthana, , India

Delft, , Netherlands

Perugia, , Italy

Osaka, , Japan

Seoul, , Korea, Republic Of

Lodz, , Poland

Riga, , Latvia

Kuala Lumpur, , Malaysia

Barcelona, , Spain

Lisboa, , Portugal

Tucson, Arizona, United States

Nottingham, , United Kingdom

Danang, , Vietnam

Ho Chi Minh, , Vietnam

Hong Kong, , Hong Kong

Bhubaneswar, , India

Ciudad Autonoma Buenos Aires, , Argentina

Criciúma, , Brazil

Campinas, , Brazil

Melbourne, Victoria, Australia

Dazhou, , China

Dongguan, , China

Deyang, , China

Ganzhou, , China

Guangzhou, , China

Daegu, , Korea, Republic Of

Chartres Cedex, , France

Lisboa, , Portugal

Bad Neustadt, , Germany

Nové Zámky, , Slovakia

Zilina, , Slovakia

East London, , South Africa

Barcelona, , Spain

Mostoles, , Spain

Beijing, Beijing, China

Washington, District Of Columbia, United States

Cremona, , Italy

Roma, , Italy

San Martin, , Argentina

Clayton, , Australia

St. Gallen, , Switzerland

New Taipei City, , Taiwan

Southport, , Australia

Cheltenham, , United Kingdom

Exeter, , United Kingdom

Nanyang, , China

Leicester, , United Kingdom

Brno, , Czechia

Taian, , China

Wuhan, , China

Praha 2, , Czechia

Winnipeg, Manitoba, Canada

Greenfield Park, Quebec, Canada

Genova, , Italy

Matsubara Shi, , Japan

Seoul, , Korea, Republic Of

Poitiers, , France

Chennai, , India

Guwahati, , India

Mumbai, , India

Ankara, , Turkey

Hyderabad, , India

Warangal, , India

Tokyo, , Japan

Evanston, Illinois, United States

Bruxelles, , Belgium

Passo Fundo, , Brazil

Porto Alegre, , Brazil

Liaocheng, , China

Praha 5, , Czechia

Yanji, , China

Zhanjiang, , China

Ajmer, , India

La Crosse, Wisconsin, United States

Varazdin, , Croatia

Brno, , Czechia

Hastings, , New Zealand

Blagoevgrad, , Bulgaria

Xuzhou, , China

Hamburg, , Germany

Rotorua, , New Zealand

Rajathevi, , Thailand

Bialystok, , Poland

Springfield, Illinois, United States

Sao Paulo, , Brazil

Pisa, , Italy

Kurume Shi, , Japan

Wichita, Kansas, United States

Pleven, , Bulgaria

Calgary, Alberta, Canada

New Hyde Park, New York, United States

Box Hill, , Australia

Woolloongabba, , Australia

Guangzhou, , China

Hangzhou, , China

Jining, , China

Linyi, , China

Nanchong, , China

Xuancheng, , China

Porto Alegre, , Brazil

Berlin, , Germany

Heidelberg, , Germany

Potsdam, , Germany

Guwahati, , India

Kozhikode, , India

Lucknow, , India

L'aquila, , Italy

Chiba, , Japan

Kawasaki City, , Japan

Gwangju, , Korea, Republic Of

Yongin Si, , Korea, Republic Of

Kuching, , Malaysia

Manila, , Philippines

Belgrade, , Serbia

Porto Alegre, , Brazil

Sevilla, , Spain

Tarragona, , Spain

Göteborg, , Sweden

Taichung, , Taiwan

Sao Jose Do Rio Preto, , Brazil

Pazardzhik, , Bulgaria

Diyarbakir, , Turkey

Hanoi, , Vietnam

Liuzhou, , China

Aberdeen, , United Kingdom

Whittier, California, United States

Aguascalientes, , Mexico

Portland, Oregon, United States

Nashville, Tennessee, United States

San Miguel De Tucuman, , Argentina

Dartford, , United Kingdom

Cincinnati, Ohio, United States

Singapore, , Singapore

Doncaster, , United Kingdom

Suzhou, , China

Vijayawada, , India

Visakhapatnam, , India

London, , United Kingdom

Wakefield, , United Kingdom

Higashihiroshima Shi, , Japan

Jinan, , China

Seoul, , Korea, Republic Of

Kure, , Japan

Seoul, , Korea, Republic Of

Plymouth, , United Kingdom

Orlando, Florida, United States

Marikina City, , Philippines

La Coruña, , Spain

Malaga, , Spain

Jeju Special, , Korea, Republic Of

Johnson City, New York, United States

Rockville, Maryland, United States

Hangzhou, , China

Tupelo, Mississippi, United States

Sofia, , Bulgaria

Kingston, Ontario, Canada

Chicago, Illinois, United States

Boston, Massachusetts, United States

Omaha, Nebraska, United States

New York, New York, United States

Adelaide, South Australia, Australia

Camperdown, New South Wales, Australia

Herston, Queensland, Australia

Kingston, , Canada

Osorno, , Chile

Dundee, , United Kingdom

New Delhi, Delhi, India

Haifa, , Israel

Haifa, , Israel

Jerusalem, , Israel

Tel Aviv, , Israel

Seoul, , Korea, Republic Of

Seoul, , Korea, Republic Of

Seoul, , Korea, Republic Of

Auckland, , New Zealand

Manila, Ncr, Philippines

Tainan, , Taiwan

Taipei, , Taiwan

Tiwi, Northern Territory, Australia

Campina Grande Do Sul, , Brazil

Beijing, Beijing, China

Patients applied

0 patients applied

Trial Officials

Janssen Research & Development, LLC Clinical Trial

Study Director

Janssen Research & Development, LLC

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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