Imaging the Pathogenesis of Cerebral Small Vessel Disease
Launched by JOHNS HOPKINS UNIVERSITY · Jan 18, 2023
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial, titled "Imaging the Pathogenesis of Cerebral Small Vessel Disease," is studying a condition known as cerebral small vessel disease (CSVD), which can lead to serious health issues like memory problems and dementia. The researchers want to understand how this disease progresses by looking at changes in the brain using MRI scans. They are especially interested in tracking white matter hyperintensities (WMH), which are changes seen on these scans that indicate CSVD.
The trial is currently recruiting participants aged 65 to 74 who have had an ischemic stroke (a type of stroke caused by a blockage in blood flow to the brain) and at least one other health issue such as high blood pressure, high cholesterol, or diabetes. Participants will need to undergo three MRI scans over approximately 1.25 years. This study is important as it aims to better understand CSVD, which could help improve care for individuals at risk of cognitive decline. If you meet the eligibility criteria and are interested, this could be a valuable opportunity to contribute to important research.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Clinical or radiographic evidence of ischemic stroke
- • One vascular risk factor (hypertension, hyperlipidemia, or diabetes)
- • Evidence of cerebral small vessel disease on MRI
- Exclusion Criteria:
- • Inability to complete 3 research MRI scans over 1.25 years
About Johns Hopkins University
Johns Hopkins University, a prestigious research institution located in Baltimore, Maryland, is renowned for its commitment to advancing medical science and public health through innovative clinical trials. With a rich history of groundbreaking research and a multidisciplinary approach, the university's clinical trial initiatives focus on translating scientific discoveries into effective treatments and interventions. Leveraging state-of-the-art facilities and a collaborative network of experts, Johns Hopkins University conducts rigorous clinical studies that aim to improve patient outcomes and address critical health challenges. Its dedication to ethical standards and participant safety underscores its role as a leader in clinical research.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Baltimore, Maryland, United States
Patients applied
Trial Officials
Richard Leigh, MD
Principal Investigator
Johns Hopkins University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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