Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

Launched by CENTRAL DENMARK REGION · Jan 19, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how different types of oxygen therapy can help patients with Chronic Obstructive Pulmonary Disease (COPD) who are having a flare-up, known as an acute exacerbation. The main goal is to see if a specific way of giving oxygen—called titrated oxygen, which mixes oxygen with air to keep oxygen levels in a target range (88-92%)—can help reduce the risk of dying within 30 days compared to standard oxygen therapy, which provides pure oxygen (100%).

To be eligible for this trial, participants need to be over 40 years old and have a confirmed diagnosis of COPD. They will be treated by emergency medical personnel who suspect they are having an acute exacerbation of their condition. Participants will receive either the titrated oxygen treatment or the standard care and will be monitored for their health over the next month. It's important to note that certain conditions, like asthma or pregnancy, may exclude someone from participating in this study. The trial is not yet recruiting participants, but it aims to provide valuable insights into better treatment options for those experiencing COPD flare-ups.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients over the age of 40
• • EMT or Paramedic suspected AECOPD
• • Confirmed suspicion of COPD
• Exclusion Criteria:
• • Bronchospasm due to asthma, allergic reaction or non-COPD conditions
• • Known or suspected pregnancy
• • Prehospital Non-invasive, invasive or assisted bag mask ventilation
• • Allergy to inhaled bronchodilators (Salbutamol)
• • Inter-hospital transfer
• • More than 2 doses (5 mg salbutamol) inhalation drug, acute treatment by EMS (emergency medical service) personnel, before allocated treatment is initiated
• • Suspicion of acute coronary syndrome