The Diabetes Prevention Program Outcomes Study AD/ADRD Project

Launched by MARINELLA TEMPROSA · Jan 19, 2023

Keywords

ClinConnect Summary

This is an observational study called the DPPOS AD/ADRD Project. It follows people who started with prediabetes or type 2 diabetes in the Diabetes Prevention Program to learn how these blood sugar conditions relate to thinking and memory problems, including dementia. Researchers will combine regular cognitive tests over several years with blood tests and brain imaging to see how brain changes line up with changes in thinking. The main goal is to classify each person’s thinking skills over time (normal, mild memory problems, or dementia) and to explore blood and brain markers that might be linked to those changes.

About who can be in the study: researchers expect to enroll around 1,900–2,000 people who were originally in the DPP and are still alive, most around age 72, with many women and a substantial portion from racial or ethnic minority groups. For brain imaging, participants must be 55 or older and able to have an MRI. Participants will have two visits to provide urine, plasma, and serum samples, plus ongoing cognitive testing; those in the brain-imaging group may have brain scans as part of the study. This is not a treatment trial—it’s a look at how prediabetes and diabetes relate to brain health, with data that will be shared with other researchers after the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All surviving participants originally randomized in the Diabetes Prevention Program
• • For Brain Imaging subcohort, only participants aged 55 years and older and those without contraindication to MRI will be included. Contraindications to MRI include the inability to lie flat, claustrophobia, and the presence of indwelling metallic objects, medical or non-medical, that are not 3T MRI compatible.
• Exclusion Criteria:
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