Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study

Launched by WEST VIRGINIA UNIVERSITY · Jan 21, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to help adults with Tourette Syndrome manage their tics. Researchers want to see if using a treatment called repetitive transcranial magnetic stimulation (rTMS) can improve the effects of a behavioral therapy known as Comprehensive Behavioral Intervention for Tics (CBIT). The study will involve two groups of participants: one group will receive the real rTMS treatment, while the other group will receive a placebo, which is a "fake" treatment that doesn't have any active effect. After the rTMS sessions, all participants will take part in eight sessions of CBIT, and the researchers will compare how well both groups do in terms of tic frequency and severity.

To be eligible for this trial, participants need to be at least 18 years old and have been diagnosed with Tourette Syndrome, showing moderate tic severity. Certain individuals, such as those with metal implants in their body, pregnant women, or those with a history of seizures, cannot participate. If you join the study, you can expect to undergo the rTMS treatment and then participate in the behavioral sessions, all while being closely monitored for any changes in your tics. This trial is currently recruiting participants and aims to better understand how these treatments might work together to improve the lives of those with Tourette Syndrome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 years or older
• • Diagnosis of Tourette Syndrome
• • Moderate Tic Severity at baseline
• Exclusion Criteria:
• • Presence of metallic objects or neurostimulators in the brain
• • Pregnancy
• • History of active seizures or epilepsy
• • Contraindications to receiving fMRI
• • Inability to participate in CBIT due to other underlying cognitive or medical condition