Cardiovascular Effects of Very Low Nicotine Content Cigarettes

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Jan 31, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how very low nicotine content cigarettes affect the heart and blood vessels in both daily and non-daily smokers. Researchers want to understand if smoking these types of cigarettes has different cardiovascular effects compared to regular cigarettes. The study is currently looking for participants aged 21 and older who have smoked at least once in the last month and are willing to smoke either the research cigarettes or their usual brand during a lab visit.

If you decide to join, you'll need to meet certain health criteria. For example, you cannot have a recent diagnosis of heart or blood vessel diseases, and you should not be pregnant or breastfeeding. During the study, you'll be asked to smoke in a controlled setting, and the researchers will monitor your heart health and other measurements. This trial aims to gather important information that could help improve smoking cessation efforts and understand the impacts of different types of cigarettes on cardiovascular health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Self-reported cigarette smoking at least once in the past 30 days
• • ≥21 years old
• • Willingness to smoke research cigarettes or usual brand cigarettes during lab visit.
• • Ability to speak, comprehend, and read English sufficiently to complete study procedures
• Exclusion Criteria:
• • Self-reported diagnosis of cardiovascular diseases like coronary artery disease, stroke, peripheral artery disease, cardiac arrhythmia, pulmonary embolism \& blood clots in legs and arm in the past 3 months
• • Body temperature ≥ 100.4˙F
• • Unstable health conditions interfering with electrocardiogram (ECG) measurements
• • Self-reported diagnosis of hyperthyroidism or thyrotoxicosis
• • Currently pregnant (as indicated by urine pregnancy test at the start of laboratory visit) or breastfeeding.
• • Currently seeking treatment to quit smoking