Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC

Launched by M.D. ANDERSON CANCER CENTER · Jan 24, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new way to treat spinal disease using a technique called spinal stereotactic radiosurgery (SRSS). This method uses advanced imaging technology called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) to target the treatment more precisely. The goal is to see if this approach can lead to better treatment results and improve the quality of life for patients with spinal issues related to cancer.

To participate in this trial, you need to be at least 18 years old and have a documented spinal disease that a doctor can confirm. You should also be a candidate for this type of radiation therapy, which means your doctor believes it could help you. Eligible patients may have up to three affected vertebrae in their spine and should have good motor strength in the area being treated. However, the trial is not open to everyone; for example, patients who are pregnant or have certain types of cancer that respond better to standard radiation treatment cannot participate. If you join the trial, you will receive focused radiation therapy while being carefully monitored to assess your response to treatment.

Gender

ALL

Eligibility criteria

• INCLUSION CRITERIA:
• • 1. Age ≥ 18 years old
• • 2. Radiographically documented disease of the spine within 4 weeks of registration (candidates with or without epidural disease allowed)
• • 3. Candidate for spine SRS/SBRT as determined by treating Radiation Oncologist or Multidisciplinary Spine Conference review
• • 4. Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated allowed
• • 5. Diagnosis of cancer documented
• • 6. Motor strength ≥ 4 out of 5 in the extremity affected by the level of spinal disease planned for radiation
• • 7. Karnofsky Performance score (KPS) ≥ 40 or ECOG score ≤ 3
• EXCLUSION CRITERIA:
• • 1. Patients with highly radiosensitive histologies likely to respond to conventional radiation therapy alone (ie lymphoma, multiple myeloma, etc)
• • 2. Patients who are unable to undergo MRI of the spine with contrast
• • 3. Patients who are pregnant