Cholecystitis From a Microbiological and Histopathological Perspective

Launched by ORGANKIRURGISK AFDELING, SYGEHUS LILLEBÆLT, KOLDING · Jan 25, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the presence of bacteria in the gallbladder and bile of patients who are having gallbladder surgery, known as cholecystectomy. The main goal is to find out if the common antibiotic treatment currently used is effective against the bacteria that often cause infections in people with gallbladder inflammation, a condition known as calculous cholecystitis. Researchers want to understand more about these infections so they can improve treatment options for patients.

To participate in this study, individuals must be at least 18 years old and agree to take part by signing a consent form. They should be scheduled for gallbladder surgery at the Department of Surgery, Sygehus Lillebælt, Kolding. However, there are some important exclusions: those who have taken antibiotics in the month before surgery, have had previous procedures on their bile ducts, or have been treated for gallbladder inflammation with antibiotics before will not be eligible. Participants can expect to have samples taken from their gallbladder during their surgery, which will help researchers gather valuable information. This trial is currently looking for volunteers, and it aims to enhance our understanding and treatment of gallbladder infections.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age above 18 years
• • Signed consent form
• • Patients having cholecystectomy performed at the Department of Surgery, Sygehus Lillebælt, Kolding.
• Exclusion Criteria:
• • Administration of any type of antibiotics one month prior to surgery in the control group.
• • Previous instrumentation of the bileducts
• • Previous clinical acute cholecystitis treated conservatively with antibiotics
• • Patients will be precluded from the studypopulation in cases of pPerioperative perforation of the gallbladder, or conversion to open cholecystectomy or in cases of failed attempts to extract bile or samples from the gallbladder wall.