Dapaglifozin to Avoid Acute Kindey Injury (AKI) to Chronic Kidney Disease (CKD) Transition: DAKI-CKD Study

Launched by INSTITUTO NACIONAL DE CIENCIAS MEDICAS Y NUTRICION SALVADOR ZUBIRAN · Jan 26, 2023

Keywords

ClinConnect Summary

The DAKI-CKD Study is a clinical trial looking at whether a medicine called dapagliflozin can help prevent patients who have experienced a serious episode of acute kidney injury (AKI) from developing chronic kidney disease (CKD) later on. Patients who are hospitalized with severe AKI will be randomly assigned to receive either dapagliflozin along with standard medical care or just the standard care alone for 21 days. The goal is to see if taking dapagliflozin can lower the chances of developing CKD over an 18-month follow-up period.

To be eligible for this trial, participants must be adults over 18 years old who have been diagnosed with severe AKI within the last 24 hours. They should not have had any previous kidney disease. Throughout the study, participants will have their blood and urine tested at several points to monitor their kidney health. This study is currently recruiting, and it aims to provide valuable insights into how we can better protect kidney function after an injury.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (aged \>18 years) with AKI 3 diagnosis for less than 24 h (KDIGO classification, creatinine level or urine output criteria), hospitalized in general admission floor and/or intensive care unit. AKI diagnosis must be compatible with the diagnosis of acute tubular necrosis in a context of ischemic or toxic aggression.
• Exclusion Criteria:
• • CKD Stage 3b (KDIGO) or more, renal transplant, urinary tract obstruction, thrombotic microangiopathy, acute glomerulopathy, cardiac arrest without awakening, oncological diagnosis with a life expectancy of less than 5 years, use of norephinephrine \>0.30 mcg/kg/min for 6 h or more, use of two vasopressors, PaO2/FiO2 ratio \<150, Type 1 DM, fasting for more than 48 h, previous inclusion in other study, pregnant or breastfeeding woman.