Neurological Recovery Following NOS-SACD

Launched by NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST · Feb 2, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how well patients recover from nerve damage caused by the recreational use of nitrous oxide, commonly known as "NOS." Young people, especially those aged 16 to 30, often use nitrous oxide for its euphoric effects, but it can lead to serious neurological problems, such as tingling, weakness, and balance issues. The study aims to follow these patients for a year to better understand the extent of their symptoms and how to manage their recovery effectively.

To participate in the trial, patients must be between 16 and 30 years old, have experienced symptoms like tingling or weakness after using nitrous oxide, and have a confirmed diagnosis of nerve damage from a neurologist. Participants will be asked to complete questionnaires about their health, which will be done remotely to make it easier for them. This research is important as it will help doctors learn more about the long-term effects of nitrous oxide abuse and improve care for those affected.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Any patient first presented with paraesthesia, weakness, ataxia or gait disturbance with a history of NOS use (age limit 16-40) as of 19/08/2024
• • Patients who can read and write in English, so that they can complete the questionnaires.
• • Patients must have received a definitive consultant neurologist confirmed diagnosis of NOS-induced neurological damage. This is possible as all eligible patients will have been reviewed by the neurology team prior to study involvement.
• Exclusion Criteria:
• • •Other causes of previous neuropathy or neurodegeneration indicated.
• Qualitative Interview Study:
• • Patients currently taking part in the longitudinal study.
• • Patients who report previously (clinical history) or currently (PHQ-2, clinical history) experiencing mental health difficulties.