UPURS Trial for Patient-centered Management of Symptomatic Obstructing Stones

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Feb 2, 2023

Keywords

ClinConnect Summary

The UPURS Trial is a research study designed to explore the best way to manage patients with symptomatic ureteral stones, which are small mineral deposits that can cause pain and discomfort when they block the ureters—the tubes that carry urine from the kidneys to the bladder. In this trial, researchers are comparing two approaches: one group of patients will receive immediate treatment with a procedure called ureteroscopy, which removes the stone, while another group will be monitored and may receive treatment later if needed. The goal is to determine which approach is more effective for managing symptoms and improving patient outcomes.

To participate in this trial, individuals must be adults over 18 years old who are experiencing symptoms like pain, nausea, or vomiting and have a ureteral stone that is at least 5mm in size, as confirmed by a CT scan. People with certain medical conditions or preferences, such as those who need immediate surgery or have specific complications, may not be eligible. Those who join the trial can expect close monitoring and care throughout the study as researchers gather information to help improve treatment for future patients with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Presenting to the Emergency Department (ED)
• • Adult (\> 18 yo)
• • ≥5mm ureteral stone diagnosed on CT scan
• • Presence of symptoms (pain, nausea, vomiting, hematuria)
• Exclusion Criteria:
• • Strict indication for stent
• • Stone burden not amenable to Ureteroscopy (URS)
• • Dirty urine analysis (UA) or positive urine culture (UCx)
• • Transplant kidney
• • Presence of conduit
• • Comorbidities not optimized for surgery
• • Strong preference for surgery or observation