Comparison of Pallidal With Subthalamic Deep Brain Stimulation for Cervical Dystonia

Launched by CHINESE PLA GENERAL HOSPITAL · Jan 29, 2023

Keywords

ClinConnect Summary

This clinical trial is looking to compare two types of deep brain stimulation (DBS) treatments for a condition called cervical dystonia, which causes involuntary twisting or tilting of the head. The researchers want to find out whether targeting a specific area in the brain called the subthalamic nucleus (STN) is more effective than targeting another area called the globus pallidus internus (GPi). By studying how these treatments affect symptoms, quality of life, and potential side effects, they hope to understand which method works better, especially in the long run.

To be eligible for the trial, participants need to be between 18 and 80 years old, have been diagnosed with cervical dystonia that hasn’t improved with medication or botulinum toxin injections, and generally be in good health aside from their condition. They should also have a normal brain scan and be willing to follow up regularly. If you or a loved one meets these criteria, you could play an important role in helping researchers find the best treatment for cervical dystonia.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• • 1. Diagnosed as idiopathic or hereditary isolated CD;
• • 2. Severe functional impairment;
• • 3. Oral medication and injection of botulinum toxin become ineffective (\> 3 months since last injection), or refuse to adopt botulinum toxin injection;
• • 4. No secondary causes of CD;
• • 5. Age 18-80 years old;
• • 6. Normal neurological examination except for dystonia;
• • 7. Normal brain MRI;
• • 8. The subject or their family members can fully understand the trial and sign the informed consent;
• • 9. Good compliance and willingness to receive regular follow-ups.
• • Exclusion criteria
• • 1. Diagnosed as secondary CD;
• • 2. CD with obvious trunk/limb involvement, or Meige syndrome;
• • 3. History of severe mental disorders, dementia, or epilepsy;
• • 4. Previous dystonia surgery (pallidotomy, thalamotomy, DBS, etc);
• • 5. Accompanied by other neurological diseases (Parkinson's disease, essential tremor, multiple sclerosis, stroke, etc);
• • 6. The patient has or needs other implantable devices (cardiac pacemakers, defibrillators, cochlear implants, spinal cord stimulators, etc);
• • 7. Pregnant women or women who are waiting to become pregnant during the trial;
• • 8. Poor health condition.