EEG/MECG/EMG Evaluating the Severity of Aortic Stenosis, Heart Failure and Ischemic Stroke Through an Artificial Intelligenceassisted System.

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · Jan 29, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how well a new system, assisted by artificial intelligence, can help detect the severity of certain heart and brain conditions, specifically aortic stenosis (a narrowing of the heart's aortic valve), heart failure, and ischemic stroke (which happens when blood flow to the brain is blocked). The researchers will use a combination of tests that measure brain, heart, and muscle activity to see if this technology can provide more accurate information about these conditions and help doctors create personalized treatment plans for patients based on their specific health needs.

To participate in this study, individuals must be at least 20 years old and may include healthy volunteers or patients with certain health issues, such as metabolic syndrome, heart failure with reduced heart function, severe aortic stenosis preparing for a heart valve replacement, or those who have had a stroke and are in intensive care. Participants will undergo tests using a special device, and while the study is not yet recruiting, it aims to improve how we understand and treat these serious health conditions. It’s important to note that individuals with certain medical histories, like those currently being treated for cancer or those who cannot complete required tests, will not be eligible to participate.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• • 1. Age≥20 year-old
• • 2. Healthy subjects or patients with A. Metabolic syndrome (MetS) ；B. HF with reduced ejection fractions (HFrEF, defined by left ventricular ejection fraction≤40%) and current or previous symptoms of HF；C. Severe aortic stenosis (defined aortic valve area \< 1.0 cm2 or mean pressure gradient ≥ 40 mmHg), preparing to receive transcatheter aortic valve replacement ；D. Acute ischemic stroke and admitted to stroke intensive care unit (ICU), within 24 hours after onset
• The criteria of MetS includes:
• • 1. Abdominal obesity: waist circumference (for Asians) ≥ 90 cm in men and ≥ 80 cm in women;
• • 2. Hyperglycemia: serum fasting glucose level ≥ 100 mg/dl, or receiving drug treatment for elevated blood sugar;
• • 3. Reduced high-density lipoprotein cholesterol (HDL-C): serum HDL-C \< 40 mg/dl in men and \< 50 mg/dl in women or on cholesterol drug treatment;
• • 4. Elevated triglycerides: serum triglyceride ≥ 150 mg/dl or on drug treatment of hypertriglyceridemia;
• • 5. Hypertension: systolic blood pressure ≥ 130 mmHg, diastolic blood pressure ≥ 85 mmHg, or on antihypertensive drug treatment.
• Exclusion criteria:
• • 1. Under treatment for malignancy
• • 2. Currently receiving immunosuppressants
• • 3. Modified Rankin Scale (mRS) ≥2 prior to the stroke
• • 4. Symptomatic HF in patients with acute ischemic stroke
• • 5. Unable to perform neurocognitive function test
• • 6. Unable to evaluate the physical activity using questionnaire or 6-minute walk test
• • 7. Unable to cooperate with examinations using 3E combo machine.