Cerebral Oxygenation and Metabolism and Severe Head Injury in Paediatrics (COMetSHIP)

Launched by CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST · Jan 29, 2023

Keywords

ClinConnect Summary

The COMetSHIP trial is studying how to better understand and improve care for children who have suffered severe head injuries, known as traumatic brain injuries. Children are particularly vulnerable to these injuries, and unfortunately, they often face serious complications and higher risks of death compared to other age groups. The researchers want to learn more about what happens in the brain after an injury, especially in the crucial hours and days that follow. They will be using special monitors to track oxygen levels and chemical changes in the brain, which could help doctors provide better treatment and protect the brain from further damage.

To participate in this study, children between the ages of 3 and 16 who have experienced a brain injury and require assistance with breathing and monitoring of pressure in their heads may be eligible. However, some children may not qualify if they have certain medical conditions or are not expected to survive more than 24 hours. Participants will have their brain activity monitored closely as part of their regular medical care, and this extra information could lead to improved treatments in the future. This trial is currently seeking volunteers, and families can expect a supportive environment focused on the best possible outcomes for their child.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients admitted with brain injury requiring ventilation and ICP monitoring
• • Age group: 3 years and 16 years (children under the age of three years are excluded as the triple bolt for multimodality monitoring is not currently used for this age group)
• Exclusion Criteria:
• • Bleeding diathesis
• • Patient unlikely to survive more than 24 hours