Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone

Launched by SHANGHAI ZHONGSHAN HOSPITAL · Jan 31, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how different positions—lying on your back (supine) versus lying on your stomach (prone)—affect lung function and breathing efforts in adults with a serious breathing problem called acute hypoxemic respiratory failure. The researchers want to see how well treatments like High-flow nasal cannula (a type of oxygen therapy) and CPAP (a machine that helps keep the airways open) work when patients are in these two positions, especially for those with COVID-19 or other respiratory issues.

To be eligible for this study, you must be an adult aged 18 to 90 who is experiencing significant breathing difficulties and needs a certain level of oxygen support. However, if you are in immediate need of a breathing tube, can’t communicate, or have certain medical conditions that prevent you from participating, you won’t be able to join. If you do take part, you can expect to receive oxygen therapy while being monitored closely, and your lung function will be assessed in both positions to help improve treatment for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • adult patients (18-90 years) who have acute hypoxemic respiratory failure, requiring FIO2 \> 0.4 to maintain SpO2 at 90-95% during HFNC at 50 L/min
• Exclusion Criteria:
• • patients who need immediate intubation; refuse to participate in the study; unable to communicate; have contraindication to place the esophageal catheter; unable to use EIT, such as open-chest surgery with chest tube placement; have contraindication for prone positioning, including pregnant, post-abdomen surgery within a week; hypercapnic respiratory failure.