Prevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell Transplant

Launched by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK) · Feb 9, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how hematopoietic stem cell transplants (HSCT), a common treatment for certain cancers and illnesses, might affect liver health. Researchers want to understand why some patients develop liver problems after their transplant and how any existing liver disease might influence the results of the transplant. By gathering information through tests and examinations, the study aims to identify factors that contribute to liver dysfunction in these patients.

To participate, individuals must be at least 18 years old or children aged 3 to 17 who are being evaluated for HSCT at the NIH Clinical Center. Participants can expect to visit the center 11 times over four years, especially during the first year. During these visits, they will undergo various tests, including physical exams, blood tests, liver biopsies (which involve taking small samples of liver tissue), imaging scans, and ultrasounds. It's important to note that pregnant or breastfeeding individuals and those unable to follow study procedures will not be eligible to participate.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• An individual who meets any of the following criteria will be included in this study:
• • Male and female adults \>=18 years of age and children 3-17 years of age
• • Undergoing evaluation for hematopoietic stem cell transplant at the NIH Clinical Center
• EXCLUSION CRITERIA:
• • An individual who meets any of the following criteria will be excluded from participation in this
• study:
• • Pregnancy or lactation
• • Unable to comply with study procedures
• • Inability to provide written informed consent