The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa
Launched by MASSACHUSETTS GENERAL HOSPITAL · Feb 1, 2023
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
A clean air intervention will be implemented in each household, including HEPA- based air filtration, solar lighting, and education. The air filtration system will be cycled monthly, with active filtration alternating with no filtration for one month on/one month off. To determine the effect of the clean air intervention within the household, PM2.5 concentration during each cycle and lung function will be measured among household members.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age \< 12 months
- • • First episode of WHO-defined severe pneumonia22: cough or difficulty breathing with
- • Oxygen saturation \< 90% or central cyanosis,
- • Severe respiratory distress, or
- • Signs of pneumonia with a general danger sign
- • Be willing to commit to entire 2 years of follow up visits.
- • (Controls) Matched to each case on age (+/-1 month), sex, and community
- Exclusion Criteria:
- • Craniofacial, cardiac or other major malformation
- • Neuromuscular condition that affects respiration
- • Outside Smart Discharges Project catchment area
- • Prior hospitalizations or known episodes of respiratory illness or episodes of pneumonia before index admission,
About Massachusetts General Hospital
Massachusetts General Hospital (MGH) is a leading academic medical center located in Boston, Massachusetts, renowned for its commitment to advancing medical research and patient care. As a prominent teaching hospital affiliated with Harvard Medical School, MGH plays a pivotal role in clinical trials across a wide range of disciplines, including cardiology, oncology, neurology, and more. The institution is dedicated to fostering innovative research that translates into effective therapies and improved health outcomes. MGH's Clinical Trials Office provides comprehensive support to facilitate the design, implementation, and management of clinical studies, ensuring adherence to the highest ethical standards and regulatory compliance. With a focus on collaboration and patient-centered care, MGH strives to enhance medical knowledge and contribute to the future of healthcare.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Mbarara, , Uganda
Patients applied
Trial Officials
Peter Moschovis, MD
Principal Investigator
Massachusetts General Hospital
Jerome Kabakyenga, MBChB, MPH, PhD
Principal Investigator
Mbarara University of Science and Technology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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