Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation

Launched by CENTRAL INSTITUTE OF MENTAL HEALTH, MANNHEIM · Feb 2, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring new ways to help people quit smoking by combining sleep improvements with chess-based training. The researchers believe that better sleep can help strengthen the memory of quitting techniques, making it easier for smokers to succeed in their efforts to stop. Participants will be monitored while they sleep and will also undergo brain scans to see how these methods work. They will be divided into four groups, where some will do high-intensity interval training along with chess training, while others will not.

To join the study, participants should be between 18 and 75 years old and must have a severe tobacco use disorder, which means they have a strong addiction to smoking. They need to be able to communicate well and give consent to take part in the trial. However, individuals with serious health conditions, a history of brain injury, or who are currently pregnant cannot participate. Those who join can expect to be involved in physical activities, brain scans, and have their sleep monitored, all aimed at helping them quit smoking successfully.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • severe tobacco use disorder (TUD) according to DSM-5
• • sufficient ability to communicate with investigators and answer questions in both written and verbal format
• • ability to provide fully informed consent and to use self-rating scales
• • right-handedness
• • HIIT can be performed without the risk of side effect (medical sports check)
• Exclusion Criteria:
• • severe internal, neurological, and/or psychiatric comorbidities; other Axis I mental disorders other than TUD according to ICD-10 and DSM 5 (except for mild depression, i.e. F32.0, adjustment disorder and specific phobias) in the last 12 months
• • history of brain injury
• • severe physical diseases
• • common exclusion criteria for MRI (e.g. metal, claustrophobia)
• • positive drug screening (opioids, benzodiazepines, barbiturates, cocaine, amphetamines)
• • psychotropic medication within the last 14 days
• • pregnancy