Neurocognition After Radiotherapy in CNS- and Skull-base Tumors

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Feb 3, 2023

Keywords

ClinConnect Summary

This clinical trial is looking to understand how different treatments for brain tumors and tumors at the base of the skull affect long-term thinking and memory abilities in adults. Participants will include adults aged 18 and older who have been diagnosed with specific types of brain tumors that can be treated with traditional radiation therapy. The study aims to see how treatments like chemotherapy, radiation, and surgery impact mental functioning over time.

If you decide to participate, you’ll be asked to fill out questionnaires about your thinking abilities and quality of life, take cognitive tests, and undergo advanced brain imaging at several points during the study. It’s important to note that some patients may not qualify, such as those with certain types of tumors that have a poorer outlook, those needing specific types of radiation therapy, or individuals with significant previous mental health issues. This trial is currently recruiting participants, and your involvement could help improve understanding of how these treatments affect brain function in the long run.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (≥ 18 years at the time of diagnosis) with a primary brain or base of skull tumour, who are amenable for conventionally fractionated radiotherapy (photon or proton irradiation)
• Exclusion Criteria:
• * Patients with tumours with poor prognostic characteristics:
• • Incompletely resected IDH-wild-type glioma
• • Completely resected IDH-wild-type and MGMT-promotor unmethylated glioma
• • grade III meningioma
• • H3K27M+ midline glioma
• • Patients with tumours requiring craniospinal irradiation (CSI)/whole ventricular irradiation (WVI)
• • Hypofractionated/stereotactic radiation (fraction sizes \> 2 Gy per fraction)
• • Inability to perform the cognitive tests or self-report inventories because of motor/sensory deficits or insufficient Dutch language proficiency
• • Mental retardation documented before diagnosis
• • Pre-diagnosis/pre-existing psychiatric diagnosis resulting in cognitive deficits like psychoses, neurodevelopmental disorders (autism/learning disorders)
• • Relapse previously treated by chemo and/or radiation therapy
• • Genetic syndrome (e.g. Down)
• • Unable to perform MR imaging (claustrophobia, metallic implants like pacemaker/ICD/neurostimulator)