Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases

Launched by I.M. SECHENOV FIRST MOSCOW STATE MEDICAL UNIVERSITY · Feb 6, 2023

Keywords

ClinConnect Summary

Evaluating of eVOCs profiles by proton mass spectrometry with a time-of-flight (PTR-TOF) in patients with different chronic respiratory diseases is of great interest for assessing the prognosis and development of severe ventilation and cardiovascular disorders.

The aim of our study is to determine the diagnostic significance of PTR-TOF analysis in patients with chronic respiratory diseases and to identify specific eVOC markers of a severe ventilation and cardiovascular disorders in patients with different chronic respiratory diseases.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Written informed consent to participate in the study;
• • 2. Age 18 and over;
• • 3. Clinical diagnosis of one of chronic respiratory diseases (COPD, bronchial asthma, cystic fibrosis, lymphangioleiomyomatosis, hypersensitivity pneumonitis or other interstitial lung disease).
• Exclusion Criteria:
• • 1. Unable to sign informed consent;
• • 2. Respiratory disease (for controls);
• • 3. Mental illness (severe dementia, schizophrenia, severe depression, manic-depressive psychosis);
• • 4. Acute coronary syndrome, acute cerebrovascular accident, pulmonary embolism within the last 3 months;
• • 5. Oncology;
• • 6. Previous lung transplantation (for patients with respiratory diseases);
• • 7. Diseases and conditions that can change the ECG picture and complicate the analysis of the ECG (conduction disturbance, pacemaker);
• • 8. Inability to use a heart monitor (congenital developmental anomalies, traumatic amputation of the upper limbs, essential tremor, Parkinson's disease);
• • 9. Pregnancy.