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Search / Trial NCT05732623

Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer

Launched by SAN RAFFAELE UNIVERSITY · Feb 7, 2023

Trial Information

Current as of July 22, 2025

Recruiting

Keywords

Early Onset Young Onset Young Adult Colon Cancer Rectal Cancer Cancer Genetics Cancer Risk Factors Diet

ClinConnect Summary

This clinical trial is looking at the risk factors that may lead to early-onset colorectal cancer (eoCRC), which is cancer of the colon or rectum diagnosed in people under 50 years old. Researchers want to understand how lifestyle choices—like diet, physical activity, and smoking—affect the chances of developing this type of cancer. They will compare patients who have been recently diagnosed with eoCRC to healthy volunteers matched by age and sex to see if there are any significant differences in their eating habits and lifestyle factors.

To be eligible for the study, participants with eoCRC must be between 18 and 49 years old and have a confirmed diagnosis. Healthy volunteers should have no history of cancer and must pass a simple stool test. Participants will be asked to fill out a food questionnaire and may undergo additional tests to help validate their responses. This study is currently recruiting and aims to gather important information that could help in understanding and reducing the risk of early-onset colorectal cancer.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • All sexes eligible
  • (for Cases) eoCRC diagnosed between 18 and 49 years and confirmed by histology (biopsy or surgical specimen in case of surgery)
  • (for Controls) negative past and present history of cancer; negative fecal occult blood test (FOBT), or negative colonoscopy.
  • Exclusion Criteria:
  • CRC diagnosed at ≥ 50 years
  • Diseases that can modify the dietary regimen (celiac disease, diabetes)
  • Diseases that are known to predispose to eoCRC (personal past or recent history of inflammatory bowel disease, past history of pelvic irradiation)
  • Unable to give written consents and to fill in the electronic questionnaire

About San Raffaele University

San Raffaele University is a prestigious academic institution located in Milan, Italy, renowned for its commitment to advancing medical research and education. As a clinical trial sponsor, the university leverages its cutting-edge facilities and collaboration with the San Raffaele Hospital to conduct innovative research aimed at improving patient outcomes. The institution is dedicated to fostering interdisciplinary approaches in clinical studies, focusing on translating scientific discoveries into practical therapies. With a strong emphasis on ethics, safety, and regulatory compliance, San Raffaele University is at the forefront of developing new treatments across various medical fields, contributing significantly to the global healthcare landscape.

Locations

Denver, Colorado, United States

Chicago, Illinois, United States

Helsinki, , Finland

Munich, , Germany

Wuppertal, , Germany

Milan, Lombardy, Italy

Oslo, , Norway

Barcelona, , Spain

Patients applied

0 patients applied

Trial Officials

Giulia Martina Cavestro, MD PhD

Principal Investigator

IRCCS San Raffaele Scientific Institute

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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