The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
Launched by TSEUNG KWAN O HOSPITAL, HONG KONG · Feb 8, 2023
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the use of a medication called Dexamethasone during a surgery known as total thyroidectomy, which is the complete removal of the thyroid gland. The goal of the study is to see if Dexamethasone can help improve patients' voices and reduce the risk of low calcium levels after the surgery. Voice problems and low calcium levels can happen in many patients after thyroid surgery, so researchers want to find ways to make recovery easier and more successful.
To be eligible for this trial, participants must be at least 18 years old and scheduled for a total thyroidectomy due to non-cancerous conditions, such as a multinodular goiter or Graves' disease. Unfortunately, those with certain health issues, like diabetes or a history of neck surgeries, cannot participate. If you join the study, you can expect to receive Dexamethasone during your surgery and have your voice and calcium levels closely monitored before and after the procedure. This research could potentially lead to better outcomes for many patients undergoing thyroid surgery in the future!
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Aged 18 or above
- • Patients undergoing total thyroidectomy for benign pathologies
- • MNG
- • Toxic nodular goitre
- • Graves' disease
- Exclusion Criteria:
- • Non-communicable patients
- • Patients contraindicated for steroid (DM, Hepatitis carrier, Tuberculosis, peptic ulcer disease)
- • Patients contraindicated for analgesics including Panadol, Celebrex, Tramadol or Levobupivacaine
- • Malignant thyroid disease
- • Patients with previous thyroid surgery, or neck surgery
- • Pre-existing hoarseness of voice of any cause or pre-existing vocal cord palsy
- • Pregnancy / Lactating female patients
- • Pre-existing renal disease / autoimmune disease on steroids
- • Patients who require steroid cover during operation e.g. hydrocortisone perioperatively
About Tseung Kwan O Hospital, Hong Kong
Tseung Kwan O Hospital, located in Hong Kong, is a leading healthcare institution dedicated to providing comprehensive medical services and advancing clinical research. As a prominent clinical trial sponsor, the hospital emphasizes innovative healthcare solutions and strives to enhance patient outcomes through rigorous scientific investigation. With a multidisciplinary approach and a commitment to ethical standards, Tseung Kwan O Hospital actively engages in various clinical trials to explore new therapies and treatment modalities, contributing to the global medical community while ensuring the highest level of patient care and safety.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hong Kong, , Hong Kong
Patients applied
Trial Officials
Jason YK Chan, MBBS
Study Director
Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong
Zenon YEUNG, MbChB
Principal Investigator
Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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