Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism

Launched by DR ADNAN AGHA · Feb 14, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of adding vitamin C to the standard treatment for patients with primary hypothyroidism, a condition where the thyroid gland does not produce enough hormones. Many people with hypothyroidism struggle to control their symptoms despite taking a medication called levothyroxine, which is meant to replace the missing hormone. The researchers want to see if vitamin C can help improve thyroid function and overall health for those who are still experiencing problems while on levothyroxine.

To participate in this trial, individuals must be at least 18 years old, have been diagnosed with primary hypothyroidism for more than six months, and have been taking levothyroxine without achieving normal thyroid levels. Participants should not have certain conditions, such as celiac disease or severe mental health issues, that could affect their ability to follow the study. Those who join the trial can expect to receive either vitamin C or a placebo (a substance with no active treatment) along with their regular medication for a specific period, allowing the researchers to compare results and determine if vitamin C makes a difference in managing hypothyroidism.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 18; both male or female
• • Diagnosed to have Primary hypothyroidism \> 6 months.
• • Under follow up in Endocrine clinic in Tawam hospital during the 6 months
• • No evidence of secondary hypothyroidism (no pituitary problems/surgery or thyroid surgery/ablation)
• • TSH \> 4 despite being on \> 1.6 ug/kg/day of Levothyroxine for more than 8 weeks
• Exclusion Criteria:
• • Presence of coeliac disease
• • Presence of selenium or iodine deficiency
• • Gastric/intestinal resection surgery or confirmed malabsorption syndromes
• • Known mental health issues affecting compliance
• • Patient unable to consent.
• • Overt biochemical hypothyroidism with TSH \> 20 or T4 \< 6