Prognosis of Cerebral Small Vessel Disease

Launched by INSEL GRUPPE AG, UNIVERSITY HOSPITAL BERN · Feb 8, 2023

Keywords

ClinConnect Summary

This clinical trial, called "Prognosis of Cerebral Small Vessel Disease," is looking at how different types of small vessel disease (SVD) affect patients' health outcomes. Small vessel disease can lead to serious problems like strokes, bleeding in the brain, and cognitive issues. The goal of this study is to understand the risks associated with various presentations of SVD, helping doctors better predict what might happen to patients based on their specific condition.

To participate in this study, patients should be experiencing symptoms related to small vessel disease, such as having had a stroke, bleeding in the brain, or significant cognitive difficulties. The study is open to adults aged 18 and over, regardless of gender. Participants can expect to have their health monitored over time, and their experiences will help researchers learn more about how different types of small vessel disease progress. It’s important to note that patients with a life expectancy of less than six months due to other health issues won't be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Hypertensive deep perforator arteriolopathy (DPA), clinically symptomatic with either ICH, ischaemic stroke, cognitive impairment or severe radiological manifestation (Fazekas ≥II)
• • Cerebral amyloid angiopathy (CAA according to modified Boston or Edinburgh criteria), clinically symptomatic with either ICH (including cSAH), amyloid spells, cognitive impairment or severe radiological manifestation (CMB≥2)
• • Other SVD (i.e. CADASIL or other sporadic or genetic SVD)
• Exclusion Criteria:
• • Life expectancy of \<6 months due to not-SVD related causes (i.e. cancer)
• • Patient is unlikely to attend follow-up visits