Evaluation of the Efficacy of Early Bunching of a FF-PCC in Patients With Severe Traumatic Hemorrhage

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Feb 21, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the use of a treatment called four-factor prothrombin complex (4F-PCC) in patients with severe traumatic bleeding. When someone experiences a major injury, they can lose a lot of blood, which can lead to serious complications and increase the risk of death. The researchers want to see if giving 4F-PCC early can help improve blood clotting and overall recovery for patients who are experiencing significant bleeding due to trauma.

To participate in this trial, individuals must be adults aged 18 to 79 who have suffered a severe injury (measured by a specific scoring system) and are bleeding actively. They should also be evaluated within three hours of their injury and expected to need a substantial amount of blood transfusions. However, certain people, such as those with a history of blood clots or severe head injuries, will not be eligible. Participants in the trial can expect to receive the treatment and be monitored closely to see how it affects their recovery. This could be an important step in finding better ways to treat patients with severe trauma and improve their chances of survival.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • (1) The age of adult trauma patients ≥18 years, \< The 80 - year - old (2) ISS\> 16 (3) emergency preview class for 1 to 2; (4) after trauma \& lt; 3 hours; Trauma induced active bleeding; (5) blood consumption (ABC) score of 2 or more, or a preliminary assessment of blood loss \& gt; 1000ml or ≥4 units of red blood cells expected to be transfused
• Exclusion Criteria:
• • (1) history of anticoagulation and antiplatelet drugs (2) has a deep venous thromboembolism (VTE) and pulmonary embolism (PE) history (3) (4) on patients with severe head injury occurred cardiac arrest patients (5) lactation, pregnant women 6 Abdominal cavity viscera perforation surgical treatment in patients with 7) in patients with sepsis shock patients with all kinds of mental illness incapacitated pet-name ruby are unknown agent for informed consent.