The Danish TURNER Cryopreservation Study

Launched by UNIVERSITY OF AARHUS · Feb 13, 2023

Keywords

ClinConnect Summary

The Danish TURNER Cryopreservation Study is looking to help girls with Turner syndrome, a condition that often leads to infertility due to early loss of ovarian function. The study aims to find out if freezing ovarian tissue can improve the chances of having babies in the future for these girls. Researchers want to answer important questions, such as whether this procedure can increase the number of pregnancies and live births, how to predict when a girl with Turner syndrome might reach menopause, and whether specific genes are linked to ovarian failure in these patients.

Girls aged 2 to 17 years old who have a specific genetic makeup related to Turner syndrome may be eligible to participate. If they join the study, they will undergo a minor surgery to remove one ovary, which will then be frozen for future use. Throughout the study, their hormone levels will be monitored to gather more information. It's important to note that girls with severe heart issues or certain genetic characteristics, such as having Y chromosome material, will not be eligible. This study is currently recruiting participants and aims to better understand and potentially improve fertility options for girls with Turner syndrome.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 45,X karyotype or other Turner variant karyotypes (45,X/46,XX mosaicism, ring X mosaicism, isochromosome X)
• • Age 2-17 years old
• • Ability to participate in a physical examination including a cardiac examination.
• • Signed consent from both parents.
• Exclusion Criteria:
• • Severe cardiac disease which inhibits safe surgery and pregnancy.
• • Karyotype with Y chromosome material
• • Mental retardation