The Effect of Faecal Microbiota Transplantation (FMT) on Eradication of Multidrug Resistant Organisms (MRO) in Intestinal Carriers

Launched by HVIDOVRE UNIVERSITY HOSPITAL · Feb 14, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether a treatment called faecal microbiota transplantation (FMT) can help eliminate multidrug resistant organisms (MRO) from the intestines. MROs are harmful bacteria that are tough to treat because they don’t respond to many antibiotics. By using FMT, which involves transferring healthy bacteria from a donor's stool into a patient's gut, researchers hope to make the intestines resistant to these hard-to-treat infections. This could help prevent serious infections that require strong antibiotics.

To participate in the trial, you need to be at least 18 years old and have tested positive for MROs in your intestines. You should be able to understand and speak either Danish or English and be capable of swallowing capsules. However, if you currently have a serious infection, a severe immune system problem, or recent abdominal surgery, you wouldn't be eligible. Participants in the trial will receive the treatment and be monitored for its effects, helping researchers understand if FMT can be a successful way to fight these resistant infections.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: minimum 18 years
• • Positive rectal PCR and/or culture for MRO
• • Ability to speak and understand Danish or English
• • Capable of swallowing the capsules
• Exclusion Criteria:
• • Current invasive infection with an MRO e.g. in abdomen, bloodstream or symptomatic urinary tract infection.
• • Severe immune deficiency (defined as current chemo treatment or neurofilocytes \< 1000/mm3
• • Pancreatitis, defined by pancreatic amylases above the upper reference limit
• • Planned or recent abdominal surgery (within 14 days)
• • Parenteral nutrition
• • Current antibiotic treatment of the same MRO as intestinal carriage
• • Terminal disease with expected survival under three months
• • Sepsis defined according to Surviving Sepsis Campaign guidelines
• • Pregnant or lactating women