Role of Fasted Exercise on Improving Cardiometabolic Health

Launched by MANCHESTER METROPOLITAN UNIVERSITY · Feb 23, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of exercising on an empty stomach (fasted exercise) compared to exercising after eating (fed exercise) and not exercising at all (control group) on heart and metabolic health. Participants will be assigned to one of these three groups and will engage in moderate cycling exercises for four weeks, three times a week. Researchers will measure changes in health indicators, such as weight and heart health, before and after the exercise period to see how different exercise conditions affect overall health.

To be eligible for the study, participants should be between the ages of 65 and 74, non-smokers, and generally healthy, with a body mass index (BMI) over 18.5. They should not be regular exercisers, meaning they should not do more than one exercise session per week. Participants should also be free from certain health conditions and injuries that could interfere with the exercise or the study's safety. If you join the study, you can expect to complete cycling exercises while receiving support from the research team, and your health will be monitored throughout the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female
• • Non-smokers
• • Physically inactive (partake in no more than one exercise session per week on average)
• • Body mass index \>18.5 kg/m2
• • Healthy as assessed by medical screening questionnaire
• • Prior recipient of local anaesthetic with no known adverse effects, no known hypersensitivity or no other health issue that may constrain the administration of lidocaine hydrochloride
• • Free from musculoskeletal injury and able to perform cycling exercise
• • Capacity to give informed consent
• Exclusion Criteria:
• • Regular exerciser
• • BMI \< 18.5 kg/m2
• • Pregnant
• • Allergy or intolerances to test meal products/ingredients (such as wheat or dairy products).
• • Recent major body weight change (+/- 3 kg in the past month)
• • Known hypersensitivity to Lidocaine Hydrochloride
• • Cardiovascular disease - complete heart block or hypovolaemia
• • Adam's-Stokes Syndrome
• • Wolff-Parkinson-White Syndrome
• • Porphyria
• • Epilepsy
• • Myasthenia Gravis
• • Other chronic medical condition or diagnosis including respiratory (eg asthma), endocrine, cardiovascular, neuromuscular disorders.
• • Taking medications or receiving treatment that may constrain the administration of lidocaine or local anaesthesia.