A Clinical Study of Fundus OCTA for the Identification of CMD

Launched by PEKING UNIVERSITY FIRST HOSPITAL · Feb 14, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating a new way to identify coronary microvascular disease (CMD), a condition that can increase the risk of serious heart problems. Researchers will use advanced imaging technology called optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) to look at the small blood vessels in the eye. They want to see if changes in these eye blood vessels can help detect CMD in patients who have undergone a specific heart test called coronary angiography.

To participate in the study, individuals must be at least 18 years old, have undergone coronary angiography at Peking University First Hospital, and have results showing no significant narrowing of their heart arteries (less than 50% blockage). Participants will need to sign a consent form and provide complete health information. Those with serious eye diseases or other conditions that could interfere with the study will not be eligible. If you join this trial, you can expect a non-invasive examination using eye imaging techniques, which could lead to better ways to identify and treat CMD in the future.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Patients who underwent coronary angiography in the Department of Cardiology, Peking University First Hospital;
• • 2. Complete baseline clinical information;
• • 3. Subject who have coronary angiography results, which shows coronary stenosis \< 50%;
• • 4. Older than 18 years;
• • 5. Subjects who have signed informed consent.
• Exclusion Criteria:
• • 1. Present serious fundus disease
• • 2. Severe cataract and other ophthalmic diseases, which affect imaging quality;
• • 3. Target coronary vessels provide collateral circulation for chronic complete occlusive lesions;
• • 4. The target coronary angiography agent is poorly filled, overlapped, or severely distorted, and cannot fully expose the location of the lesion;
• • 5. Coronary angiography images are of poor quality and cannot be identified;
• • 6. Active bleeding state;
• • 7. Severe renal insufficiency, contrast agent allergy, and unable to perform coronary angiography.