Cohort Study of Adrenogenic Autonomic Cortisol Secretion

Launched by CHONGQING MEDICAL UNIVERSITY · Feb 16, 2023

Keywords

ClinConnect Summary

This clinical trial is focused on understanding a condition called adrenogenic autonomic cortisol secretion in Chinese adults. The aim is to explore how this condition develops, how it can be diagnosed, and what treatments might be effective. Researchers want to learn more about the role of certain adrenal nodules (small growths on the adrenal glands) and how they affect cortisol levels in the body. High cortisol levels can lead to various health issues, so this study is important for improving diagnosis and treatment options.

To participate in this study, individuals must have specific criteria. You may be eligible if you have adrenal nodules that are at least 10 mm in size and if a test shows that your cortisol levels are higher than normal after a specific examination. However, there are several conditions that would exclude someone from participating, such as having certain adrenal tumors or serious health issues that could complicate the study. The trial is not yet recruiting participants, so there will be more information available once it starts. If you decide to participate, you will need to sign a consent form to confirm your willingness to join the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • CT examination revealed adrenal nodules (maximum diameter ≥10mm);
• • Serum cortisol \> 50nmol/L after 1mg dexamethasone inhibition test (1mg-DST).
• Exclusion Criteria:
• • Patients with primary aldosteronism (PA), pheochromocytoma, adrenal metastatic carcinoma, congenital adrenal hyperplasia (CAH), ganglionic neuroma/paraganglioma, schwannoma, adrenal hematoma and those with no definite diagnosis were evaluated by clinical and endocrine function.
• • Patients with serious underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamic-pituitary-adrenal axis (HPA axis); Pregnancy.
• • Patients with a history of alcoholism, fatigue, trauma, infection, depression, glucocorticoid use, and other drugs affecting the function of the hypothalamic-pituitary-adrenal axis.
• • Patients who are not willing to participate in and complete this study refuse to sign the written informed consent for this study.