Contrast-Enhanced Ultrasound vs Conventional US-guided Percutaneous Needle Biopsy for Pancreatic Diseases: Prospective Multicenter Randomized Controlled Trial

Launched by XIAO-YAN XIE · Feb 15, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at two different methods for taking biopsies (tissue samples) from the pancreas to help diagnose pancreatic diseases. One method uses conventional ultrasound (a common imaging technique), while the other uses a newer technique called contrast-enhanced ultrasound (CEUS) that might provide better images. The goal is to see if the CEUS-guided biopsy gives more accurate results compared to the traditional method.

To participate in this study, you need to be at least 18 years old and have certain pancreatic lesions that can be seen through imaging tests. It’s important that you don’t have a history of treatments like chemotherapy or significant health issues that could affect your participation. If you join the trial, you will have a biopsy performed using one of the two methods being studied, and your health will be monitored throughout the process. This trial is not yet recruiting participants, but it’s designed to help improve how doctors diagnose pancreatic diseases in the future.

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Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years, WHO/ECOG scores \<2;
• • Radiographic examination reveal focal pancreatic lesions;
• • No history of local treatment for pancreatic lesions, systemic chemotherapy, targeting, immunotherapy, etc;
• * Normal organ function, including the following criteria:
• • 1. Routine blood test: Hb≥80 g/L; PLT≥50×109/L;
• • 2. Coagulation function test: PT\<20s.
• Exclusion Criteria:
• • The lesions could not be shown by ultrasound and contrast-enhanced ultrasound;
• • Allergic to ultrasound contrast agent;
• • Cardiovascular and cerebrovascular diseases, liver, kidney and lung failure with significant clinical symptoms;
• • History of unexplained bleeding, severe anemia, bleeding tendency or uncorrected coagulopathy;
• • Combined with active infection;
• • Massive ascites;
• • Patients or family members do not agree to enter the study;
• • Pregnant or lactating women;
• • The investigator considers that there are any other factors that may be inappropriate for inclusion or affect the subject's participation in the study.