Feasibility of Semaglutide in Advanced Lung Disease

Launched by UNIVERSITY OF PENNSYLVANIA · Feb 15, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating whether semaglutide, a medication commonly used to treat diabetes and obesity, can be safely used by patients with advanced lung diseases like interstitial lung disease, chronic obstructive pulmonary disease (COPD), and pulmonary hypertension. The researchers want to find out if patients can handle the treatment and if it can help them reach a healthier weight over 12 weeks.

To participate, individuals must be over 18 years old, have a BMI (body mass index) of over 30, and require supplemental oxygen during physical activity. They will undergo tests to assess their lung function and body composition before and after the treatment period. Participants will also be asked about any side effects they might experience while taking semaglutide. It’s important to note that this trial is not for those with diabetes, pregnant or breastfeeding individuals, or anyone with certain medical histories. If you or someone you know is interested, this trial is currently recruiting participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of one of the following lung diseases: interstitial lung disease, sarcoidosis, chronic obstructive pulmonary disease, or pulmonary hypertension
• • Age \> 18
• • BMI \> 30 kg/m2
• • Requires supplemental oxygen on exertion
• • Stable treatment regimen X 90 days
• • Use of disease-modifying therapy
• Exclusion Criteria:
• • Diabetes
• • Pregnant or Breastfeeding
• • Recent weight loss
• • Recent or chronic GI complaints
• • History of gastroparesis
• • History of scleroderma
• • Hospitalized at time of evaluation
• • Use of weight loss medication in last 90 days
• • Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia (type 2)
• • Uncontrolled thyroid disease
• • History of acute/chronic pancreatitis
• • Prior suicide attempt
• • Suicidal ideation in last 90 days
• • Presence of a pacemaker or defibrillator