Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute ACL Injuries
Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Feb 27, 2023
Trial Information
Current as of August 20, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the effectiveness of two different approaches for treating acute injuries to the anterior cruciate ligament (ACL), a key ligament in the knee. Traditionally, many patients have surgery right after an ACL injury, but some recent studies suggest that immediate surgery may not always lead to better outcomes, like returning to sports or preventing future knee problems. This trial aims to verify those findings and see if certain factors, like symptoms, strength, and MRI results, can help predict which patients might do well with rehabilitation and possibly avoid surgery altogether.
To participate in this trial, individuals must have experienced a knee injury due to a twisting motion and seek medical advice within four weeks. They should be at least 16 years old and have a diagnosis of ACL injury confirmed by an MRI. However, those with previous ACL injuries, knee surgeries, or certain other conditions will not be eligible. Participants can expect to be a part of a study that could help doctors better understand the best treatment options for ACL injuries. This is important for tailoring care to each patient’s needs and improving recovery outcomes. The trial is currently recruiting participants of all genders.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Rotational trauma to a knee that had no previous serious injury and for which medical advice was sought within 4 weeks after the injury.
- • Medical diagnosis of ACL insufficiency including MRI (both partial and complete ruptures)
- • Minimum of 16 years
- Exclusion Criteria:
- • Participant has a history of a previous ACL injury or knee surgery to the index knee
- • Indication for acute surgery because of related injuries to the knee
- • Female who is pregnant or plans to become pregnant in the first 4 months of the trial. Since MRI assessment cannot be performed.
About Universitaire Ziekenhuizen Ku Leuven
Universitaire Ziekenhuizen KU Leuven is a leading academic medical center in Belgium, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. Affiliated with KU Leuven, one of Europe’s premier universities, the institution integrates cutting-edge scientific inquiry with high-quality patient care. It plays a pivotal role in the development and implementation of clinical trials, fostering collaboration between researchers, healthcare professionals, and industry partners to translate scientific discoveries into effective treatments. The hospital's multidisciplinary approach ensures comprehensive patient safety and ethical standards, positioning it as a trusted sponsor in the realm of clinical research.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Leuven, , Belgium
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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