Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Patients With Uncomplicated Plasmodium Falciparum Malaria

Launched by NOVARTIS PHARMACEUTICALS · Feb 17, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness and safety of different anti-malarial medications for patients with uncomplicated Plasmodium falciparum malaria, which is a type of malaria that does not cause severe symptoms. The trial is currently recruiting participants who are at least 12 years old and have a confirmed case of this type of malaria. To be eligible, participants must meet certain health criteria, such as having a specific level of malaria parasites in their blood and not having serious health conditions like severe anemia or liver disease.

Participants in this study can expect to receive anti-malarial treatment and will be monitored by healthcare professionals throughout the trial to ensure their safety and assess how well the medications work. It’s important to note that individuals who are pregnant or nursing, as well as those with certain heart conditions, may not be eligible. This research aims to find better treatment options for malaria, helping improve outcomes for patients affected by this disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male and female patients ≥18 years of age for Part A, ≥12 years of age for Part B and 2 to \<12 years of age for Part C at screening.
• • 2. Patients must have acute uncomplicated P. falciparum malaria mono infection at screening confirmed by a parasite count between 5,000 to 150,000 asexual parasite count/μl of blood for P. falciparum for Part A and between 1,000 to 150,000 asexual parasite count/μl of blood for Parts B and C.
• • 3. Patients in Part A must weigh between 40 kg and 90 kg. Patients in Part B must weigh between 35 kg and 90 kg at screening. Patients in Part C must weigh at least 10 kg at screening.
• • 4. Axillary temperature ≥ 37.5ºC or oral/tympanic/rectal temperature ≥ 38.0ºC; or history of fever during the previous 24 hours.
• Exclusion Criteria:
• • 1. Patients with signs and symptoms of severe/complicated malaria at screening or mixed Plasmodium infection (i.e., infection with more than one malaria species) at screening
• • 2. Moderate to severe anemia, chronic hemoglobinopathy (Hemoglobin level \< 8 g/dL), or known chronic underlying disease such as sickle cell disease at screening
• 3. Known clinically significant liver disease (e.g., chronic hepatitis, liver cirrhosis (compensated or decompensated), history of hepatitis B or C, hepatitis A or B vaccination in the last 3 months, known gallbladder or bile duct disease, acute or chronic pancreatitis. Clinical or laboratory evidence of any of the following at screening:
• • AST/ALT \> 3 x the upper limit of normal range (ULN), regardless of the level of total bilirubin
• • AST/ALT \> 1.5 and ≤ 2 x ULN and total bilirubin is \> ULN
• • Total bilirubin \> 2 x ULN, regardless of the level of AST/ALT
• • 4. Any known/suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection at screening.
• • 5. Pregnant or nursing (lactating) women, women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using methods of effective contraception, and sexually active patients not willing to practice effective contraception.
• 6. History or current diagnosis of ECG abnormalities indicating significant risk of safety for patients participating in the study such as:
• • Concomitant clinically significant cardiac arrhythmias, e.g., sustained ventricular tachycardia, and clinically significant second or third degree AV block without a pacemaker
• • History of familial long QT syndrome or known family history of Torsades de Pointe.
• • Resting heart rate (physical exam or 12 lead ECG) \< 50 bpm
• • Other protocol-defined inclusion/exclusion criteria may apply.